Council of Scientific and Industrial Research

Shashi Bhushan

Ram Asrey Vishwakarma

Sandip Bibishan Bharate

Santosh Kumar Guru

Sonali Sandip Bharate

Prashant Joshi

Dilip Manikrao Mondhe

Girish Badrinath Mahajan

Mubashir Javed Mintoo

Suresh Kumar

Ajay Kumar

Paramvir Singh Ahuja

Ajit Kumar Saxena

Vikas Kumar

Ashok Kumar

Shreyans Kumar Jain

Samdarshi Meena

Aashiq Hussain

Parduman Sharma

Asif Khurshid Qazi

Anup S Pathania

Akanksha Behl

Baljinder Singh

Shabber Mohammed

Abid Hamid

Zahoor Wani

Garikapati Dyva Kiran Babu

Sakshi Gupta

Garikapati Divya Kiran Babu

Rammohan Rao Yadav

Mohit Sharma

Anup Singh Pathania

The present invention relates to fused pyrimidines of formulae I and II wherein, R, Rare as herein described. The present invention particularly relates to isoform selective PI3K&#x3b1; inhibition and their medicinal use as anticancer agents. 

Fused pyrimidines as isoform selective phosphoinositide-3-kinase-alpha inhibitors and process for preparation thereof

The present invention relates to 6-aryl-4-phenylamino quinazolines of formula I wherein, R and R' are as herein described. The present invention particularly relates to synthesis and anticancer and phoshpoinositide-3-kinase-&#x3b1; (PI3K-&#x3b1;) inhibitory activity. In addition, the invention relates to methods of using compounds for treating or preventing various cancers such as pancreatic, prostate, breast and melanoma. 

6-aryl-4-phenylamino-quinazoline analogs as phosphoinositide-3-kinase inhibitors

The present invention relates to the rohitukine (5,7-dihydroxy-8-(3-hydroxy-1-methyl-piperidin-4-yl)-4H-chromen-4-ones) analogs of formula A and pharmaceutically acceptable salts thereof. In addition, the invention relates to pharmaceutically acceptable compositions comprising at least one such compound, and methods of using the compounds for treating or preventing various proliferative disorders such as melanoma, leukemia, breast cancer and prostate cancer etc. [insert Formula A here] wherein, n=0 or 1, when n=1, the dotted line indicates the double bond. 

Rohitukine analogs as cyclin-dependent kinase inhibitors and a process for the preparation thereof

The present invention relates to the compounds of formula I wherein R is as herein described. The present invention particularly relates to synthesis and antiproliferative activity of 10-substituted colchicinoids. Compounds of the invention can be used for prevention or in the treatment of cancer disease. 

10-substituted colchicinoids as potent anticancer agents

The invention pertains to a method and apparatus for separation of seeds from fruit pulp/skin/twigs, in general, coming out from juice producing industry as a waste and in particular from apple pomace. The method involves addition of apple pomace and water in a particular ratio to a vessel (), mixing with an agitator () at optimum rpm for sufficient period, allowed to stand followed by secondary agitation. Based on difference in bulk density, seeds were separated from pomace. The seedless pomace withdrawn from horizontal () or inclined () outlets and seeds collected in seed collection chamber were removed through bottom valve (). The seed trap () provided at inclined outlet () helps in their retention in the vessel (). The seedless pomace is recovered by filtration from water. This spent water can be recycled for few times and then purged. Easy to handle separation device is energy efficient, compactly designed and can be used to separate the seeds efficiently up to 97%.

Method and apparatus for the separation of seeds from fruit pulp/slurry/pomace

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Jammu, India

Shashi Bhushan