S.d. Sight Diagnostics Ltd.

Yeda Research and Develpment & Co. Ltd

Sharon Pecker

Joseph Joel Pollak

Yochay Shlomo Eshel

Amir Zait

Sarah Levy Schreier

Arnon Houri Yafin

Dan Gluck

Trevor Ruggiero

Sarah Levy

Daniel Levner

Natalie Lezmy

Noam Yorav-raphael

Yonatan Halperin

Itamar Weiss

Aidan John Carroll

Amitai Franklin

Shahal Ilani

Avishai Benyamini

Jonah Waissman

Assaf Hamo

Maayan Honig

Ilani Shahal

Apparatus and methods are described including preparing a blood sample for analysis by depositing the blood sample within a sample chamber (), and placing the sample chamber, with the blood sample deposited therein, within a microscopy unit (). One or more microscopic images of the sample chamber () with the blood sample deposited therein are acquired, using a microscope of the microscopy unit. Based upon the one or more images, an amount of one or more cell types within the sample chamber that had already settled within the sample chamber, prior to acquisition of the one or more microscopic images is determined. A characteristic of the sample is determined, at least partially in response thereto. Other applications are also described.

Accounting for errors in optical measurements

Apparatus and methods are described for use with a microscopy unit that comprises an objective lens and a microscope camera. A cantilever includes an objective lens housing. A motor moves the cantilever along a direction of the optical axis of the objective lens. The cantilever is configured, during the movement of the cantilever, to support the objective lens within the objective lens housing such that an optical axis of the objective lens is aligned with the camera, without the objective lens being directly connected to the camera. Other applications are also described.

Microscopy unit

Apparatus and methods are described including measuring hematocrit within a blood sample, by performing a first measurement on a first portion of the blood sample. Mean corpuscular volume in the blood sample is measured, by performing a second measurement on a second portion of the blood sample, the second portion being diluted with respect to the first portion. A red blood cell count per unit volume within the blood sample is determined by dividing the hematocrit measured within the first portion by the mean corpuscular volume measured within the second portion. Other applications are also described.

Performing optical measurements on a sample

Apparatus and methods are described including placing a first portion of a biological sample into a source sample portion chamber of a sample carrier, and placing a second portion of the biological sample into a diluted sample portion chamber. The second portion of the biological sample is diluted with respect to the first portion of the biological sample. Using an optical measurement device, a bulk-level measurand of the sample that relates to a parameter of the biological sample as a whole is measured, by performing a measurement upon the first portion of the biological sample. Microscopic images of the second portion of the biological sample are acquired. Other applications are also described.

Performing measurements on a sample

Apparatus and methods are described including placing a sample into a sample carrier that comprises a plurality of regions having upper and lower surfaces, having respective heights that are different from each other, and being configured such that cells form a monolayer, the monolayer within respective regions of the sample carrier having respective, different densities from each other, due to the respective regions of the sample carrier having respective heights that are different from each other. Microscopic images are acquired of each of the plurality of regions. Measurements are performed upon cell types that have a relatively high density upon microscopic images of a region of the sample chamber having a relatively low height, and measurements are performed upon cell types that have a relatively low density upon microscopic images of a region of the sample chamber having a relatively great height. Other applications are also described.

Sample carrier for optical measurements

Apparatus and methods are described for determining a property of a biological sample. A sample carrier () includes one or more sample chambers () that define at least a first region () and a second region (), the height of the one or more sample chambers varying between the first and second regions in a predefined manner. A computer processor () receives data relating to a first optical measurement that is performed upon a portion of the sample that is disposed within the first region, receives data relating to a second optical measurement that is performed upon a portion of the sample that is disposed within the second region, and determines the property of the sample by using a relationship between the first optical measurement, the second optical measurement, and the predefined variation in height between the regions. Other applications are also described.

Apparatus and methods are described for use with a blood sample (), including measuring hemoglobin concentration within at least a portion () of the blood sample, by performing a first measurement on the blood sample. Mean corpuscular hemoglobin in the blood sample () is measured, by performing a second measurement on the blood sample (). A parameter of the blood sample is determined, based on a relationship between the concentration of hemoglobin and the mean corpuscular hemoglobin. Other applications are also described.

A method for use in construction of an electronic device and a transistor structure are presented. The method comprising: providing one or more nanotubes grown on a surface of a first substrate; providing a desired electrode arrangement fabricated on a surface of a second substrate. The electrode arrangement comprises at least two elevated source and drain electrodes and one or more gate electrodes located in between said elevated source and drain electrodes. The method also comprises bringing the electrode arrangement on the second substrate to close proximity with the first substrate such that surfaces of the first and second substrates face each other; scanning said first substrate with said electrode arrangement and determining contact of electrodes of the electrode arrangement with a nanotube located on the first substrate; and detaching said nanotube from the first substrate to provide a transistor structure comprising an isolated nanotube between the source and drain electrodes.

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Rehovot, Israel

Sharon Pecker