Zymogenetics, Inc.

Ares Trading S.a.

Mayo Foundation for Medical Education and Research

Zymogenetrics, Inc.

Sharon J Busby

Mark J Murray

Virender M Labroo

Kathleen L Berkner

Frederick S Hagen

Herve Broly

Margaret Y Insley

Richard G Woodbury

Charles L Gray

Ivan Nestorov

Jane A Gross

Eric Sievers

Arnaud Ythier

Stephen M Ansell

Orestis Papasouliotis

Alain Munafo

Jan Öhrström

Jennifer Visich

Claudia Pena Rossi

In various embodiments, the present invention provides methods and compositions for treatment of autoimmune diseases, including rheumatoid arthritis, for example comprising administering to a patient in need of such treatment a TACI-Ig fusion molecule. In one embodiment, the TACI-Ig fusion molecule is administered in amount sufficient to slow, suppress or inhibit proliferation-inducing functions of BlyS and APRIL.

Methods for treating autoimmune diseases using a TACI-Ig fusion molecule

Methods are disclosed for producing proteins having biological activity for blood coagulation mediated by Factor VIIa or Factor IX. The proteins are produced by mammalian host cells which have been stably transfected with a DNA construct containing a nucleotide sequence which codes at least partially for either Factor VII or Factor IX. The nucleotide sequence comprises a first nucleotide sequence encoding a calcium binding domain, joined to a second nucleotide sequence positioned downstream of the first sequence. The second sequence encodes a catalytic domain for the serine protease activity of either Factor VIIa or Factor IX. The joined sequences code for proteins having substantially the same biological activity for blood coagulation as either Factor VIIa or Factor IX.

Expression of factor VII and IX activities in mammalian cells

The present invention provides methods and compositions for treatment of B-cell malignancies, including non-Hodgkin's lymphoma, comprising administering to a patient in need of the treatment a TACI-Ig fusion molecule in amount sufficient to suppress proliferation-inducing functions of BlyS and APRIL.

Methods for treating B-cell malignancies using a TACI-Ig fusion molecule

Polypeptides of from about 9-120 amino acid residues comprising a truncated segment of fibrinogen which may be flanked by elastomeric peptides, wherein the polypeptides are cross-linkable by a transglutaminase, homo- and copolymers containing such polypeptides are disclosed. The homo- and co-polymers disclosed herein are useful in tissue sealant and wound healing formulations.

Transglutaminase cross-linkable polypeptides and methods relating thereto

Polypeptides of from 3-120 amino acid residues comprising a segment of the formula Gln-Y-Lys, wherein Y is a spacer peptide of 1 to 12, wherein said polypeptides are cross-linkable by a transglutaminase, homo- and copolymers containing such polypeptides are disclosed. The homo- and co-polymers disclosed herein are useful in tissue sealant and wound healing formulations.

Methods are disclosed for producing proteins having biological activity for blood coagulation mediated by Factor VIIa. The proteins are produced by mammalian host cells which have been stably transfected with a DNA construct containing a nucleotide sequence which codes at least partially for either Factor VII. The nucleotide sequence comprises a first nucleotide sequence encoding a calcium binding domain, joined to a second nucleotide sequence positioned downstream of the first sequence. In particular, the first nucleotide sequence may be derived from a genomic clone or cDNA clone of Factor VII. The second sequence encodes a catalytic domain for the serine protease activity of Factor VIIA. The joined sequences code for proteins having substantially the same biological activity for blood coagulation as Factor VIIa.

Expression of factor VII activity in mammalian cells

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Seattle, WA, United States of America

Sharon J Busby