Sirna Therapeutics, Inc.

Sharon F Jamison

Leonid Beigelman

James A McSwiggen

Chandra Vargeese

Nassim Usman

Weimin Wang

James D Thompson

Shawn Patrick Zinnen

Peter Haeberli

Tongqian Chen

Pamela Pavco

Kathy L Fosnaugh

David Morrissey

Bharat Chowrira

Dennis G Macejak

Narendra K Vaish

The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to synthetic chemically modified small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against target nucleic acid sequences. The small nucleic acid molecules are useful in the treatment of any disease or condition that responds to modulation of gene expression or activity in a cell, tissue, or organism.

RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)

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Boulder, CO, United States of America

Sharon F Jamison