Organovo, Inc.

Inregen

L'oreal

Prokidney

Tengion, Inc.

Regenmedtx, LLC

Oregon Health & Science University

Regenmed, Inc.

Sharon C Presnell

Deborah Lynn Greene Nguyen

Shelby Marie King

Benjamin R Shepherd

Vivian A Gorgen

Roger M Ilagan

Andrew T Bruce

Manuel J Jayo

Oluwatoyin A Knight

Russell W Kelley

Shay M Wallace

Eric S Werdin

Sumana Choudhury

Timothy A Bertram

Justin B Robbins

John W Ludlow

Deepak Jain

Joydeep Basu

Kelly Guthrie

Richard Payne

Namrata D Sangha

H Scott Rapoport

Darell McCoy

Christopher W Genheimer

Craig R Halberstadt

Thomas Spencer

Elias A Rivera

Bryan R Cox

Neil F Robins

Patricia D Tatsumi

Jessica J Reinsch

Benjamin Watts

Keith Murphy

Kelsey Nicole Retting

Chirag B Khatiwala

Guive Balooch

Stephen L Pentoney, Jr

Scott Dorfman

Harry Scott Rapoport

Kelly I Guthrie

Frank C Lin

Dwayne E Carter

Rami Nasrallah

Alice Chen Walters

Rhiannon Hardwick

Ellen Langer

Brittany Allen-Petersen

Julien Demaude

Elizabeth Wu

Jessica Langer

Colin M O'Neill

Vaidehi Joshi

Samir Damle

Clay Platt

Rosalie Sears

Scott H Rapoport

Frank Lin

Darrell Mccoy

Iii Evinger Albert J

Darell Mccoy

Deborah Lynn Nguyen

Stephen Pentoney

Neil F Robbins

Disclosed are living, three-dimensional tissue constructs for in vitro scientific and medical research, arrays thereof, and methods of making said tissues and arrays.

Engineered tissues for in vitro research uses, arrays thereof, and methods of making the same

The invention is directed to three-dimensional, engineered, bioprinted biological tissue constructs exhibiting a liver disorder, methods of making the constructs, and use of the constructs in assays, such as drug testing and molecular diagnostic testing, including methods of assessing the ability of a candidate therapeutic agent to reverse, reduce, or prevent a liver disorder, and methods for biomarker discovery.

Use of engineered liver tissue constructs for modeling liver disorders

The present invention concerns bioactive renal cell populations, renal cell constructs, and methods of making and using the same.

Bioactive renal cells

Disclosed herein are improved methods for fabricating bioprinted, three-dimensional, biological tissues. The methods relate to exposures to low temperatures, incubations at low temperatures of various durations, and fabrication in environments without structural cross-linking treatments.

Methods for tissue fabrication

Disclosed are methods of assessing the ability of a candidate therapeutic agent to reverse, reduce or prevent renal injury by a potential toxic agent using a three-dimensional, engineered, bioprinted, biological renal tubule model. Also disclosed are methods of assessing the effect of an agent on renal function, the method comprising contacting the agent with a three-dimensional, engineered, bioprinted, biological renal tubule model. Also disclosed are models of renal disorder. In one embodiment, disclosed are models of renal fibrosis, comprising a three-dimensional, engineered, bioprinted, biological renal tubule model. Also disclosed are methods of making the model of renal disorder. In one embodiment disclosed are methods of making the model of renal fibrosis comprising contacting a three-dimensional, engineered, bioprinted, biological renal tubule model with an agent that is capable of inducing interstitial fibrotic tissue formation.

Use of engineered renal tissues in assays

Disclosed are renal tissues and arrays thereof that include a layer of renal interstitial tissue, the renal interstitial tissue comprising renal fibroblasts and endothelial cells; and a layer of renal epithelial tissue, the renal epithelial tissue comprising renal tubular epithelial cells, the renal epithelial tissue in contact with the layer of renal interstitial tissue to form a three-dimensional, engineered, biological renal tissue. Also disclosed are methods of fabricating and using the same.

Engineered renal tissues, arrays thereof, and methods of making the same

Described are three-dimensional, engineered, biological breast tissues, adipose tissues, and tumor models, including breast cancer models.

Engineered three-dimensional breast tissue, adipose tissue, and tumor disease model

Disclosed are bioprinted, three-dimensional, biological skin tissues comprising: a dermal layer comprising dermal fibroblasts; and an epidermal layer comprising keratinocytes, the epidermal layer in contact with the dermal layer to form the three-dimensional, engineered, biological skin tissue. Also disclosed are arrays of engineered skin tissues and methods of making engineered skin tissues.

Engineered three-dimensional skin tissues, arrays thereof, and methods of making the same

Engineered, living, three-dimensional liver tissue constructs including: one or more layers, wherein each layer contains one or more liver cell types, the one or more layers cohered to form a living, three-dimensional liver tissue construct free of pre-formed scaffold. Also disclosed are arrays and methods of making the same.

Engineered liver tissues, arrays thereof, and methods of making the same

The present invention concerns bioactive renal cells populations, renal cell constructs, and methods of making and using the same.

The invention is directed to isolated renal cells, including tubular and erythropoietin (EPO)-producing kidney cell populations, and methods of isolating and culturing the same, as well as methods of treating a subject in need with the cell populations.

Isolated renal cells and uses thereof

Growing community of inventors

San Diego, CA, United States of America

Sharon C Presnell