Nitto-Denko Corporation

Sharon Avkin-Nahum

Elena Feinstein

Wenbin Ying

Joseph E Payne

Igor Mett

Yoshiro Niitsu

Hagar Kalinski

Yasunobu Tanaka

Mohammad Ahmadian

Victor Knopov

Richard P Witte

Violetta Akopian

Loren A Perelman

Kenjiro Minomi

Yun Liu

Priya Prakash Karmali

John Gaudette

Zheng Hou

Sridhar C Nagarajan

What is described is a method for treating a fibrotic disease by administering a pharmaceutical composition comprising a drug carrier, which comprises a lipid and a retinoid, and a double-stranded nucleic acid molecule, which comprises an antisense sequence to mRNA encoding human hsp47.

Method for treating fibrosis using siRNA and a retinoid-lipid drug carrier

What is described is a pharmaceutical composition for treating a fibrotic disease comprising a drug carrier, which comprises a lipid and a retinoid, and a double-stranded nucleic acid molecule, which comprises an antisense sequence to mRNA encoding human hsp47.

Retinoid-lipid drug carrier

What is described are pharmaceutical compositions comprising a double-stranded nucleic acid molecule comprising a sense strand and an antisense strand wherein the sense and antisense strands are selected from the oligonucleotides described as SERPINH1_2 (SEQ ID NOS: 60 and 127), SERPINH1_45a (SEQ ID NOS: 98 and 165), and SERPINH1_51 (SEQ ID NOS: 101 and 168), and drug carrier comprising a mixture of a retinoid and a lipid vesicle, and methods of using these pharmaceutical compositions to treat a disease associated with hsp47 expression, including fibrosis.

Retinoid-liposomes for treating fibrosis

What is described are pharmaceutical compositions comprising a double-stranded nucleic acid molecule comprising a sense strand and an antisense strand wherein the sense and antisense strands are selected from the oligonucleotides described as SERPINH(SEQ ID NOS: 60 and 127), SERPINH(SEQ ID NOS: 98 and 165), and SERPINH(SEQ ID NOS: 101 and 168), and drug carrier comprising a mixture of a retinoid and a lipid vesicle, and methods of using these pharmaceutical compositions to treat a disease associated with hsp47 espresssion, including fibrosis.

Retinoid-liposomes for enhancing modulation of HSP47 expression

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Nes Ziona, Israel

Sharon Avkin-Nahum