Teva Pharmaceutical Industries Limited

Sharon Avhar-Maydan

Revital Lifshitz-Liron

Shlomit Wizel

Judith Aronhime

Tamas Koltai

Nurit Perlman

Tamar Nidam

Lilach Hedvati

Anna Balanov

Yuriy Raizi

Rami Lidor-Hadas

Michael Pinchasov

Amihai Eisenstadt

Eti Kovalevski-Ishai

Revital Ramaty

Eyal Gilboa

Elena Ben Moha-Lerman

Meital Cohen

Gabapentin enacarbil was prepared and purified from intermediates such as 1-haloalkyl carbamate or carbonate and diacid acetal skeleton. For example, a 1-haloalkyl carbonate or carbamate was prepared by combining a Cto Calcohol or Cto Cprimary amine, a solvent selected from the group consisting of: acetonitrile, Cto Cketone, Cto Cether, Cto Cester, Cto Chydrocarbon and a combination thereof; a 1-haloalkyl haloformate of the following formula: wherein each X is independently selected from Br, I, or Cl; Ris alkyl or H; and a Cto Ctertiary amine.

Processes for the preparation and purification of gabapentin enacarbil

Provided are crystalline forms of fluvastatin sodium and processes for their preparation.

Fluvastatin sodium crystal forms, processes for preparing them, compositions containing them and methods of using them

Provided are crystalline forms of Cinacalet HCl and processes for their preparation.

Crystal forms of Cinacalcet HCI and processes for their preparation

Provided are processes for the synthesis of R-(+)-3-(carbamoylmethyl)-5-methylhexanoic acid and salts thereof, intermediates in the synthesis of S-pregabalin.

Processes for the preparation of R-(+)-3-(carbamoyl methyl)-5-methylhexanoic acid and salts thereof

Provided are polymorphic forms of fluvastatin sodium and processes for their preparation.

Provided is amorphous cinacalcet hydrochloride, processes for the preparation thereof, and pharmaceutical compositions therewith.

Amorphous cinacalcet hydrochloride and preparation thereof

Processes for preparing cinacalcet are provided.

Process for preparing Cinacalcet hydrochloride

The invention provides processes for the preparation of cinacalcet hydrochloride crystalline Form I.

Processes for preparing cinacalcet hydrochloride crystal Form I

Provided are new crystalline Forms III, IV, V and VI of clopidogrel hydrogensulfate and the amorphous form of clopidogrel hydrogensulfate, as well as their pharmaceutical compositions, and method of treatments with such compositions. Also provided are novel processes for preparation of clopidogrel hydrogensulfate Form I, Form II, Form III, Form IV, Form V, Form VI and amorphous form.

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Givataym, Israel

Sharon Avhar-Maydan