Max-planck-gesellschaft Zur F&#xf6;rderung Der Wissenschaften E. V.

Idorsia Pharmaceuticals Ltd

Vaxxilon Ag

Sharavathi Guddehalli Parameswarappa

Claney Lebev Pereira

Peter H Seeberger

Marilda Lisboa

Chakkumkal Anish

Arne Von Bonin

Bopanna Monnanda

Benjamin Schumann

Subramanian Govindan

Sylvia Oestreich

Jessica Przygodda

Naeem Khan

Heung Sik Hahm

Lennart Lykke

Madhu Emmadi

Christopher Martin

Dominea Rathwell

Felix Bröcker

Petra Menova

Ju Yuel Baek

Paulina Kaplonek

Fei-Fei Xu

Adam Calow

Adam Daniel James Calow

The present invention relates to a synthetic saccharide of general formula (I) that is related toserotype O1, O2, O2ac, and O8 O-polysaccharide and carbapenem-resistantST258 O-polysaccharide and conjugate thereof. Said synthetic saccharide, said conjugate and pharmaceutical composition containing said synthetic saccharide or said conjugate are useful for prevention and/or treatment of diseases associated with. Furthermore, the synthetic saccharide of general formula (I) is useful as marker in immunological assays for detection of antibodies againstbacteria.

Vaccine against klebsiella pneumoniae

Vaccine against

The present invention relates to immunogenic compositions comprising a conjugate of a saccharide fromserotype 8 and a carrier protein, and a mixture consisting of capsular polysaccharides fromserotypes 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F individually conjugated to CRMcarrier protein, or a mixture consisting of capsular polysaccharides fromserotypes 1, 4, 5, 6B, 7F, 9V, 14, 18C, 19F and 23F individually conjugated to a carrier protein, wherein the capsular polysaccharides fromserotypes 1, 4, 5, 6B, 7F, 9V, 14, and 23F are individually conjugated to protein D, the capsular polysaccharide fromserotype 18C is conjugated to tetanus toxoid and the capsular polysaccharide fromserotype 19F is conjugated to diphtheria toxoid. Said compositions are useful for the prevention and/or treatment of diseases caused by

Pneumococcal polysaccharide-protein conjugate composition

The present invention relates to synthetic saccharides of general formula (I) that are related toserotype 8 capsular polysaccharide, conjugates thereof and the use of said saccharides and conjugates for raising a protective immune response in a human and/or animal host. Furthermore, the synthetic saccharide structures of general formula (I) are useful as marker in immunological assays for detection of antibodies againstbacteria.

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The present invention provides a protein- and peptide-free conjugate comprising a synthetic carbohydrate and a carrier molecule, wherein the synthetic carbohydrate is atype 3 capsular polysaccharide related carbohydrate and the carrier molecule is a glycosphingolipid. Said conjugate and pharmaceutical composition thereof are useful for immunization against diseases associated with, and more specifically against diseases associated withtype 3.

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Berlin, Germany

Sharavathi Guddehalli Parameswarappa