Nestec S.a.

Sony Group Corporation

Sony Corporation

Biora Therapeutics, Inc.

Progenity, Inc.

Societe Des Produits Nestle S.a.

Prometheus Laboratories Inc.

Sony Corporation of America

Pierian Holdings, Inc.

Prometheus Biosciences, Inc.

Enumera Molecular, Inc.

Other

Katholieke Universiteit Leuven

Monogram Biosciences, Inc.

Bt Bidco, Inc.

Sharat Singh

Tracy Matray

Phillip Kim

Mitchell Lawrence Jones

Christopher Loren Wahl

Xinjun Liu

Shui Long Wang

Michael VanBrunt

Harry Stylli

Linda Ohrmund

Jeanne Harvey

Limin Liu

Robert Barham

Fred Princen

Scott Hauenstein

Steven Lockton

Bruce P Neri

Nicholas Chi-Kwan Ling

Fabiyola Selvaraj

Stefan Westin

Anjali Jain

Matthew Sekedat

Ronald David Beaubien, Jr

Belen Ybarrondo

Jeffrey Buis

Jeff Perry

C Frederick Battrell

Amin R Mazloom

Venkateswarlu Kondragunta

Tani Lee

Shui-Long Wang

Richard Kirkland

Steve Lockton

Nicholas Hoe

Hua Gong

Pankaj Oberoi

Kevin Howe

Jared Salbato

Natalie Mae Jameson-Kiesling

Arana Perera

Chandni Jain

Matthew L Cooper

Po-Ying Chan-Hui

Mark Sasha Drlik

Robert Stanford Magyar

Rajiv Dua

Hossein Salimi-Moosavi

Richard Giulio Del Mastro

Ali Mukherjee

Aaron Olafur Laurence Philippsen

Nicholas David Allan

Yining Shi

Sailaja Pidaparthi

Lyndal Hesterberg

Lisa Croner

Derren Barken

Thomas Stockfisch

Severine Vermeire

Melissa Jackson

John Mccutcheon

Christopher Boyce

Michael Vanbrunt

Eriko Matsui

Ryan Paul McGuinness

Allison Luo

Severine Vermiere

Marc Ferrante

Mohammad Abbasi

Leonard Eggleston

Frederick A Fletcher

Kelly D Hester

Dunrui Wang

Karen A F Copeland

Uining Shi

Katherine Drake

Kevin David Howe

Jr Ronald David Beaubien

Po-Ying Chan-hui

Lisa J Croner

Shaoying Lee

Aruna Perera

The present invention provides methods for personalized therapeutic management of a disease in order to optimize therapy and/or monitor therapeutic efficacy. In particular, the present invention comprises measuring an array of one or a plurality of biomarkers at a plurality of time points over the course of therapy with a therapeutic agent to determine a mucosal healing index for selecting therapy, optimizing therapy, reducing toxicity, and/or monitoring the efficacy of therapeutic treatment. In certain instances, the therapeutic agent is a TNFα inhibitor for the treatment of a TNFα-mediated disease or disorder.

Methods of disease activity profiling for personalized therapy management

Compounds useful as fluorescent or colored dyes are disclosed. The compounds have the following structure (I): or a stereoisomer, tautomer or salt thereof, wherein R, R, R, R, R, L, L, L, L, M, m and n are as defined herein. Methods associated with preparation and use of such compounds are also provided.

Ultra bright dimeric or polymeric dyes with spacing linker groups

Compounds useful as fluorescent or colored dyes are disclosed. The compounds have the following structure (I): or a stereoisomer, tantomer or salt thereof, wherein R, R, R, R, R, L, L, L, L, L, L, L, L, M, M, q, w, m and n are as defined herein. Methods associated with preparation and use of such compounds are also provided.

Polymeric dyes with linker groups comprising deoxyribose

Compounds useful as fluorescent or colored dyes are disclosed. The compounds have the following structure (I), or a stereoisomer, tautomer or salt thereof, wherein R, R, R, R, R, L, L, L, L, M, M, m and n are as defined herein. Methods associated with preparation and use of such compounds is also provided.

Polymeric tandem dyes with linker groups

Compounds useful as fluorescent or colored dyes are disclosed. The compounds have the following structure (I): or a stereoisomer, tautomer or salt thereof, wherein R, R, R, R, R, L, L, L, L, M, M, m and n are as defined herein. Methods associated with preparation and use of such compounds is also provided.

This disclosure features methods and compositions for treating inflammatory disorders or conditions that arise in a tissue originating from the endoderm using an immune modulator.

Method of formulating a pharmaceutical composition comprising administering an immune modulator to the small intestine

This disclosure features methods and compositions for treating diseases of the gastrointestinal tract with a JAK or other kinase inhibitor.

Treatment of a disease of the gastrointestinal tract with a JAK or other kinase inhibitor

This disclosure features methods and compositions for treating diseases of the gastrointestinal tract with an immunosuppressant.

Treatment of a disease of the gastrointestinal tract with an immunosuppressant

Compounds useful as biologically active compounds are disclosed. The compounds have the following structure (I): or a stereoisomer, tautomer or salt thereof, wherein R, R, R, L, L, L, L, M and n are as defined herein. Methods associated with preparation and use of such compounds is also provided.

Programmable polymeric drugs

The present disclosure relates to gastrointestinal (GI) tract detection methods, devices and systems.

Gastrointestinal tract detection methods, devices and systems

Compounds useful as fluorescent or colored dyes are disclosed. The compounds have the following structure (I): (I) or a stereoisomer, tautomer or salt thereof, wherein R, R, R, R, R, L, L, L, L, L, L, L, L, M, M2, q, w, m and n are as defined herein. Methods associated with preparation and use of such compounds are also provided.

Compounds useful as fluorescent or colored dyes are disclosed. The compounds have the following structure (II): or a stereoisomer, tautomer or salt thereof, wherein R, R, R, R, R, L, L, L, L, M, m and n are as defined herein. Methods associated with preparation and use of such compounds are also provided.

Ultra bright dimeric or polymeric dyes

Compositions and methods, systems, and kits for detecting and quantifying variations in numbers of molecules, particularly variations in gene dosage, e.g., due to gene duplication, or to variations from the normal euploid complement of chromosomes, e.g., trisomy of one or more chromosomes that are normally found in diploid pairs, without digital sequencing.

Methods, systems, and compositions for counting nucleic acid molecules

Growing community of inventors

Rancho Santa Fe, CA, United States of America

Sharat Singh