Applied Research Systems Ars Holding N.v.

Merck Serono S. A.

Laboratoires Serono S.a.

Sharad Magar

Adulla P Reddy

David Rogers Buckler

Nabil El Tayer

Andreas Goutopoulos

Matthias Schwarz

Xuliang Jiang

Russell Thomas

Stephen Arkinstall

Yihua Liao

Peter Blume-Jensen

Antonio Arulanandam

Roustem Nabioullin

John Yingsheng Zhang

Russell J Thomas

Stephen J Arkinstall

The invention provides 2-carboxamide piperazine compounds, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more such compounds. Compounds of the invention are useful for the treatment of mammalian infertility.

Piperazine derivatives and methods of use

The invention provides 2-carboxamide piperazine compounds of formula I, R.IN\'N&#x2dc;&#x2032;RI(0)z-oRI wherein R&#x2032;, R, Rand Rare as defined in the claims and methods of treatment and pharmaceutical compositions that utilize or comprise one or more such compounds. Compounds of the invention are useful for the treatment of mammalian infertility.

The invention provides substituted pyrazolidinone compounds, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more such compounds. Compounds of the invention are useful for a variety of therapies, including treating or preventing various cancers, inflammation, septic shock, preterm labor, infertility, pain, and ischemia, and other diseases and disorders associated with MEK-1 and/or ERK-2 activation.

Azole derivatives and pharmaceutical compositions containing them

&ldquo;The present invention provides non-peptidic amino derivatives, their therapeutic use as well as pharmaceutical compositions that possess activity as Follicle Stimulating Hormone (FSH) agonists and are useful in the treatment of infertility. In particular, the invention provides derivatives.&rdquo;

FSH mimetics for the treatment of infertility

The present invention provides non-peptidic amino derivatives, their therapeutic use as well as pharmaceutical compositions that possess activity as Follicle Stimulating Hormone (FSH) agonists and are useful in the for treatment of infertility. In particular, the invention provides cyclic and acyclic alpha- and beta-aminocarboxamides, more particularly tetrahydroisoquinolinecarboxamides, piperidinecarboxamides, pyrrolidinecarboxamides, and 2-amino-3-carboxamidopyridine derivatives.

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Canton, MA, United States of America

Sharad Magar