Amersham Plc

Neuro Imaging Technologies, LLC

Ge Healthcare Limited

Shaoyin Wang

John L Neumeyer

Richard A Milius

Robert B Innis

Gilles D Tamagnan

Gilles Tamagnan

Iodinated neuroprobes for mapping monoamine reuptake sites in the brain, and particularly iodinated neuroprobes that can also serve as radiotracers for use in single-photon emission computed tomography (SPECT) and positron emission tomography (PET) for imaging of such reuptake sites, are disclosed. Precursors of radiolabeled iodinated neuroprobes, both with and without a radiotracer atom, and kits for preparing the radiolabeled iodinated neuroprobes are also disclosed.

Neuroprobes for mapping monoamine reuptake sites

An iodinated neuroprobe is provided for mapping monoamine reuptake sites. The iodinated neuroprobe is of the formula: ##STR1## wherein R= ##STR2## wherein n=2-8; R'=C.sub.w H.sub.2w+1 wherein w=0-6 and C includes an isotope of carbon; and X=an isotope of Cl, an isotope of Br, an isotope of F, an isotope of I, or Sn(R'.sub.1 R'.sub.2 R'.sub.3), wherein

Halogenated neuroprobe for mapping monoamine reuptake sites

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Lexington, MA, United States of America

Shaoyin Wang