Xenon Pharmaceuticals Inc.

Genentech, Inc.

Novartis Ag

Novartis Pharma Gmbh

Shaoyi Sun

Sultan Chowdhury

Jianmin Fu

Rajender Kamboj

Shifeng Liu

Serguei Sviridov

Vishnumurthy Kodumuru

Zaihui Zhang

Alla Yurevna Zenova

Qi Jia

Nagasree Chakka

Duanjie Hou

Vandna Raina

Christoph Martin Dehnhardt

Michael Edward Grimwood

Mikhail A Chafeev

Thilo Focken

Ivan William Hemeon

Brian Salvatore Safina

Michael Scott Wilson

Melwyn A Abreo

Michael D Winther

Jean-Christophe Andrez

Heinz W Gschwend

Natalia Pokrovskaia

Wenbao Li

Natalie Alysia Dales

Jianyu Sun

Chi Tu

Paul Robert Bichler

Tom Hsieh

Daniel P Sutherlin

Daniel Fred Ortwine

Mark W Holladay

Mark Wood

Daniel F Harvey

Simon James Gauthier

Jean-Jacques Alexandre Cadieux

Jun M Li

Jian-Min Fu

Tarek Suhayl Mansour

Richard Masten Fine

Boris Klebansky

Kristen Nicole Burford

Steven Sigmund Wesolowski

Mark Gray-Keller

Mehran Seid Bagherzadeh

Julia Fonarev

Jonathan David Langille

Mikhail Kondratenko

Abid Hasan

Wei Gong

Lauren Fraser

Philippe Bergeron

Shannon Marie Decker

Robert Fraser

Tao Sheng

Amy Frances Douglas

Zoran Cikojevic

Zhiguo Liu

Jiuxiang Zhu

Verner Alexander Lofstrand

Sengen Sun

Cindy J Hudson

Kashinath Sadalapure

Andrew D White

Chien-An Chen

Mehran Bagherzadeh

Renata Marcella Oballa

Chien-an Chen

Jung Yun Kim

Juliette Sabbatani

Jan Felix Scholtes

Wei Zhang

Paul Charifson

Helen Clement

Shifeng Lui

Shawn Johnstone

Rajender K Kamboj

Mikhail Chafev

Jun Li

Jian-min Fu

Mikhail A Kondratenko

The present disclosure is directed to compounds of formula (1):

Pyridine derivatives and their use as sodium channel activators

This invention is directed to benzenesulfonamide compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment of diseases or conditions associated with voltage-gated sodium channels, such as epilepsy and/or epileptic seizure disorders.

Heteroaryl-substituted sulfonamide compounds and their use as therapeutic agents

The invention provides compounds having the general Formula (I); and pharmaceutically acceptable salts thereof; wherein the variables R, R, subscript n, subscript q, ring A, X, L, subscript m, X, R, R, R, R, R, D and E have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

Therapeutic compounds and methods of use thereof

The invention provides compounds having activity as sodium channel (e.g., NaV1.7) inhibitors that are useful for treating sodium channel-mediated diseases or conditions, such as pain, as well as other diseases and conditions associated with the mediation of sodium channels, and compositions containing such compounds and methods for using such compounds and compositions.

Substituted benzamides and methods of use thereof

The invention provides compounds having the general Formula (I); and pharmaceutically acceptable salts thereof; wherein the variables R, R, subscript n, subscript q, ring A, X, L, subscript m, X, R, R, R, R, R, D and E have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions. 

The invention provides novel compounds having the general formula: and pharmaceutically acceptable salts thereof, wherein the variables R, subscript n, ring A, X, L, subscript m, X, B, R, R, R, R, Rand Rhave the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

N-substituted benzamides and methods of use thereof

The invention provides compounds having the general formula I: and pharmaceutically acceptable salts thereof, wherein the variables R, R, subscript n, ring A, X, L, subscript m, X, R, R, R, R, R, and Rhave the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

This invention is directed to benzensulfonamide compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment of sodium channel-mediated diseases or conditions, such as pain.

Benzenesulfonamide compounds and their use as therapeutic agents

The invention provides compounds having the general formula: [insert formula (I)] (I) and pharmaceutically acceptable salts thereof, wherein the variables R, subscript n, ring A, X, L, subscript m, X, R, R, R, R, and Rhave the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions. 

Substituted triazolopyridines and methods of use thereof

The invention provides compounds having the general formula (I): and pharmaceutically acceptable salts thereof, wherein the variables RA, subscript n, ring A, X, L, subscript m, X, R, R, R, R, and Rhave the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions. 

Substituted benzoxazoles and methods of use thereof

This invention is directed to asymmetric syntheses of certain spiro-oxindole derivatives, which are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.

Asymmetric syntheses for spiro-oxindole compounds useful as therapeutic agents

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Coquitlam, Canada

Shaoyi Sun