University of Washington

Bloodworks

Puget Sound Blood Center

Shaoyi Jiang

Hong Xue

Shengfu Chen

Zheng Zhang

Norman David Brault, Jr

Louisa Ruth Carr

Priyesh Jain

Daniel M Ratner

Jill Marie Johnsen

Yuting Li

James T Kirk

Harihara Subramanian Sundaram

José A López

Yung Chang

Andrew William Sinclair

Andrew Keefe

Hana Vaisocherova

Jean-René Ella-Menye

Gang Cheng

Tao Bai

Wei Yang

Bowen Li

Hsiang-Chieh Hung

Buddy D Ratner

Jonathan Himmelfarb

Chun-Jen Huang

Peng Zhang

Jinrong Ma

Yang Li

Caroline Tsao

Dianyu Dong

Chenjue Tang

Joel MacArthur

Qiuming Yu

Xuewei Xu

Changlu Gao

Guozhu Li

Luo Mi

Zhiqiang Cao

Lei Zhang

Xiaojie Lin

Mary Elizabeth O'Kelly

Jose A Lopez

Jean René Ella-Menye

Zwitterionic double network hydrogels, methods for making zwitterionic double network hydrogels, methods for using zwitterionic double network hydrogels, and articles made from and coated with zwitterionic double network hydrogels.

Zwitterionic double network hydrogels

Zwitterionic phosphatidylserine (ZPS) monomers, ZPS polymers and ZPS copolymers, methods for making the ZPS monomers, ZPS polymers, and ZPS copolymers, compositions and materials that include ZPS polymers and ZPS copolymers, and methods for using the ZPS monomers, ZPS polymers, and ZPS copolymers.

Immunosuppressive materials and related methods

N-oxide and monomers, N-oxide polymers and copolymers, methods for making the N-oxide monomers, polymers, and copolymers, compositions and materials that include N-oxide polymers and copolymers, and methods for using the N-oxide monomers, N-oxide polymers, and N-oxide copolymers.

N-oxide and ectoine monomers, polymers, their compositions, and related methods

Free-standing non-fouling polymers and polymeric compositions, monomers and macromonomers for making the polymers and polymeric compositions, objects made from the polymers and polymeric compositions, and methods for making and using the polymers and polymeric compositions.

Free-standing non-fouling polymers, their compositions, and related monomers

Zwitterionic carboxybetaine copolymers and their use in coatings to impart non-fouling and functionality to surfaces, particularly surfaces of blood-contacting medical devices.

Zwitterionic copolymer coatings and related methods

Photonic devices, systems, and methods for detecting an analyte in a biological solution (e.g., whole blood) are provided. Representative photonic devices are optical ring resonators having nanoscale features and micron-sized diameters. Due to the compact size of these devices, many resonators can be disposed on a single substrate and tested simultaneously as a sample is passed over the devices. Typical analytes include blood cells, antibodies, and pathogens, as well as compounds indicative of the presence of blood cells or pathogens (e.g., serology). In certain embodiments, blood type can be determined through photonic sensing using a combination of direct detection of blood cells and serology. By combining the detection signals of multiple devices, the type of blood can be determined.

Photonic pathogen detection

Functionalized zwitterionic and mixed charge polymers and copolymers, methods for making the polymers and copolymers, hydrogels prepared from the functionalized zwitterionic and mixed charge polymers and copolymers, methods for making and using the hydrogels, and zwitterionic and mixed charge polymers and copolymers for administration for therapeutic agents.

Functionalized zwitterionic and mixed charge polymers, related hydrogels, and methods for their use

Photonic blood typing

Marine coatings including cationic polymers hydrolyzable to nonfouling zwitterionic polymers, coated marine surfaces, and methods for making and using the marine coatings.

Marine coatings

Nonfouling copolymers and hydrogels comprising positively charged repeating units or latent positively charged repeating units and negatively charged units or latent positively charged units.

Mixed charge copolymers and hydrogels

Zwitterionic polymer and mixed charge copolymer bioconjugates, methods for making and using the bioconjugates.

Zwitterionic polymer bioconjugates and related methods

Dual-functional nonfouling surfaces and materials, methods for making dual-functional nonfouling surfaces and materials, and devices that include dual-functional nonfouling surfaces and materials. The dual-functional surfaces are nonfouling surfaces that resist non-specific protein adsorption and cell adhesion. The dual-functional surfaces and materials include covalently coupled biomolecules (e.g., target binding partners) that impart specific biological activity thereto. The surfaces and materials are useful in medical diagnostics, biomaterials and bioprocessing, tissue engineering, and drug delivery.

Dual-functional nonfouling surfaces comprising target binding partner covalently coupled to polymer attached to substrate

Hierarchical films with structurally regulated functionalities through the integration of two-dimensional and three-dimensional structures to achieve ultra low nonspecific binding and high loading of molecular recognition elements, and methods for making and using the films.

Hierarchical films having ultra low fouling and high recognition element loading properties

Growing community of inventors

Redmond, WA, United States of America

Shaoyi Jiang