Warner-lambert Company

Takeda Pharmaceutical Company Limited

Polaris Group

Jiarui Biopharmaceuticals, Ltd.

Jiaray Pharmaceuticals, Inc.

Shaosong Chu

Philip Erickson

Jeffrey Alan Stafford

Michael Brennan Wallace

Zhe Nie

Zhiyuan Zhang

John David Lawson

Xiaoming Li

Jerome C Bressi

Lily Kwok

Mallareddy Komandla

Kraig M Yager

Sanjib Das

Carin L Perretta

Krzysztof Appelt

Philip Eugene Erickson

Peptide-drug conjugates comprising p-aminobenzyl carbamoyl or p-aminobenzolyl carbonate self-immolating linkers are disclosed. The peptide-drug conjugates comprise a peptide moiety that can be cleaved by cellular proteases, bound to the self-immolating linker, which linker is bound to a cytotoxic drug moiety. Upon cleavage of the peptide moiety, the linker self-immolates, releasing the cytotoxic drug in active form. Dimeric structures of the peptide drug conjugates comprising two molecules of cytotoxic drug per conjugate are also disclosed.

Peptide-drug conjugates

Compounds of the following formula are provided for use with cMET: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using the compounds.

cMET inhibitors

Pyrimidine- and triazine-based chemical compounds that are useful, for example, as protein kinase inhibitors for treating cancer, neurological disorders, autoimmune disorders, and other diseases, and methods of using such compounds.

Protein kinase inhibitors

Compounds comprising an indazolyl group and a thiazolyl group, preferably 7-substituted 3-(thiazol-2-yl)-1H-indazole compounds in which the indazolyl group and a thiazolyl group are each independently optionally substituted, are useful for the treatment or prophylaxis of bacterial infections in mammals. The compounds are believed to function by inhibiting gyrase B.

Gyrase inhibitors

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Encinitas, CA, United States of America

Shaosong Chu