International Business Machines Corporation

Agency for Science, Technology and Research

Shaoqiong Liu

James L Hedrick

Yi Yan Yang

Jeannette M Garcia

Amanda Catherine Engler

Daniel Joseph Coady

Dylan J Boday

Rudy J Wojtecki

Nathaniel H Park

Alshakim Nelson

Zhen Chang Liang

Ashlynn Lingzhi Lee

Yang Chuan

Gregory Breyta

Chuan Yang

Wei Han

Kazuki Fukushima

Robert J Ono

Mu San Zhang

Jed Walter Pitera

Hareem Tariq Maune

Julian M W Chan

Jye Yng Teo

A stimulus-responsive micellar carrier, methods that may be associated with making a stimulus-responsive micellar carrier, and methods that may be associated with using a stimulus-responsive micellar carrier are disclosed. The stimulus-responsive micellar carrier comprises a cargo molecule, and a linear block copolymer having a hydrophilic block connected to a hydrophobic block by a stimulus-responsive junction moiety. The micellar carrier can be supplied to a patient body for therapeutic purposes, such as the treatment of cancerous tissue. A method of preparing or obtaining a stimulus-responsive micellar carrier may include preparing a polyethylene glycol material having an acetal end group and then preparing a block copolymer by forming a reaction mixture including the polyethylene glycol material, a cyclic carbonate monomer, and a base.

Stimulus-responsive micellar carrier

A number of cationic antimicrobial polymers have been synthesized by a condensation polymerization in bulk. The initial polymer formed has backbone tertiary nitrogens, which are subsequently quaternized using a suitable quaternizing agent (e.g., alkyl halide). The cationic polymers include polyamides, polycarbonates, polypolyureas and polyguanidiniums having a cationic repeat unit comprising the quaternary ammonium nitrogen as a backbone nitrogen. The cationic polymers can be active against Gram-negative, Gram-positive microbes, and/or fungi.

Condensation polymers for antimicrobial applications

A cationic bis-urea compound is disclosed of formula (1): wherein:

Cationic bis-urea compounds as effective antimicrobial agents

A covalently crosslinked hydrogel comprises a) three or more divalent poly(alkylene oxide) chains P' covalently linked at respective first end units to a branched first core group C&#x2032;, b) three or more divalent poly(alkylene oxide) chains P&#x2033; covalently linked at respective first end units to a branched second core group C&#x2033;, the chains P&#x2033; comprising respective second end units which are covalently linked to between 0% and 100% of respective second end units of chains P&#x2032; by divalent linking groups L&#x2033;, and c) at least one pendant cationic block copolymer chain A&#x2032;-B&#x2032;. A&#x2032;-B&#x2032; comprises i) a divalent block A&#x2032; comprising a poly(alkylene oxide) backbone chain having an end unit covalently linked to a second end unit of one of the chains P&#x2032; by a divalent linking group L&#x2032;, and ii) a monovalent block B&#x2032; comprising a first repeat unit, the first repeat unit comprising a backbone carbonate group and a cationic side chain group.

Antimicrobial hydrogels, methods of preparation thereof, and articles therefrom

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Singapore, Singapore

Shaoqiong Liu