Jiangsu Huaiyu Pharmaceutical Co., Ltd.

Shanghai Pharmaexplorer Co., Ltd.

Jiangsu Hyamab Pharmaceutical Co., Ltd.

Pharmaexplorer Limited

Shanghai Hyamab Biotech Co., Ltd.

Shaoping Hu

Lile Liu

Qing Duan

Tatchi Teddy Yang

Xinxiu Yang

Hongzhuan Gu

Mingming Pan

Jun Yang

Yu Zhang

Jian Yuan Wu

Jing Gao

Wei Shao

Yingying Hu

Yan Liu

Shiyong Gong

Yanyan Li

Heng Pan

Lina Wang

Xiaodan Cao

Xiaohui Shao

Hu Liu

Yizhen Yang

Haishan Luo

Yuandong Wang

Xiaolan Sun

Qin Zhong

Zhengrong Shuai

Zihan Jin

Ying Gu

Stewart Leung

Siran Zhu

Xiaoxuan Lan

Zhiqiang Xu

Lijuan Hao

Lini Huang

Yangyang Zhai

Haohan Liu

Yingying Gao

Provided are a murine or fully human monoclonal antibody targeting SEMA4D and a preparation method therefor, wherein the antibody binds to the SEMA4D antigen and has activities such as combating tumors.

SEMA4D antibody, preparation method therefor and use thereof

Provided in the present invention are a 4-1BB antibody and a preparation method and the use thereof. In particular, provided in the present invention are a 4-1BB antibody, which has high affinity to 4-1BB protein, can effectively activate the signal downstream of the 4-1BB and significantly increase expression quantities of IFN-&#x3b3; and IL-2 in human mixed lymphocytes or T lymphocytes, and can be used to treat cancers and autoimmune diseases.

4-1BB antibody and preparation method and use thereof

The present invention discloses IL-13 antibody, method of its preparation and use thereof. The IL-13 antibody comprises one or more of heavy chain CDR1, heavy chain CDR2 and heavy chain CDR3 of heavy chain variable region of the IL-13 antibody, and/or one or more of light chain CDR1, light chain CDR2, and light chain CDR3 of light chain variable region of the IL-13 antibody. The IL-13 antibody has a high affinity and can significantly inhibit the secretion of thymus activation-regulated chemokine and periostin as well as the expression of vascular cell adhesion molecule-1 induced by IL-13, it can significantly inhibit airway hyperresponsiveness in mice induced by IL-13, and therefore can be used in the preparation of drugs for preventing or treating IL-13 expression or dysfunction related diseases.

IL-13 antibody and preparation method and use thereof

Provided herein are anti-PD-L1 antibodies and antigen-binding fragments thereof. Also provided are nucleic acids encoding the antibodies, compositions containing the antibodies, and methods of producing the antibodies and using the antibodies for treating or preventing diseases such as cancer, infectious diseases and autoimmune diseases.

Anti-PD-L1 antibodies and uses thereof

Anti-PCSK9 antibodies and antigen-binding fragments thereof are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, and methods of producing the antibodies and using the antibodies for treating or preventing diseases such as lipid disorders, metabolic diseases, hypercholesterolemia, inflammatory diseases and infectious diseases.

Anti-PCSK9 antibodies and uses thereof

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Shanghai, China

Shaoping Hu