Hoffmann-la Roche Inc.

Roche Vitamins Inc.

F. Hoffmann-la Roche Ag

Shaoning Wang

Michelangelo Scalone

Reinhard Reents

Christophe Pfleger

Hans-Juergen Mair

Andreas Zogg

Werner Bonrath

Alexander Flohr

Frank Kienzle

Hans Iding

Bjoern Bartels

Rudolf Schmid

Kurt Puentener

Urs Schwitter

Charles Alois Dvorak

Paul Spurr

Jean-Michel Adam

Pius Waldmeier

Olaf Grassmann

Ursula Hoffmann

Eric Roy Humphreys

Helmut Werner Stahr

Serena Maria Fantasia

Justin Philip Vitale

René Trussardi

Stefan Abrecht

Franziska E Rohrer

Francois Montavon

Michel Lalonde

Xianqing Shi

Andre Bubendorf

Regina Moog

Armin Ruf

Stephan Goetzoe

Wolfgang Goehring

Pankaj D Rege

Uwe Klinkhammer

Daniel Fishlock

Marian Zajac

Eric R Humphreys

The present invention relates to a process for the preparation of S-[2-[1-(2 -ethylbutyl)cyclohexylcarbonylamino]-phenyl] 2-methylthiopropionate which is useful as a pharmaceutically active compound.

Process

The present invention is concerned with a novel process for the preparation of a compound of formula I and its hydrates  The compounds of formula I and the corresponding hydrates are pharmaceutically active substances.

(3,4-dichloro-phenyl)-((S)-3-propyl-pyrrolidin-3-yl)-methanone hydrochloride and manufacturing processes

The invention relates to a novel process for the preparation of 2-phenyl-[1,2,4]triazolo[1,5-a]pyridine derivatives of formula I or of a salt thereof  2-Phenyl-[1,2,4]triazolo[1,5-a]pyridine derivatives of formula I with their 1,2,4-triazole nucleus build the structural core of a great number of functionalized molecules in medicinal chemistry.

Process for the preparation of 2-phenyl-[1,2,4]triazolo[1,5-a]pyridine derivatives

The present invention relates to a process for the preparation of S-[2-[1-(2-ethylbutyl)cyclohexylcarbonylamino]-phenyl]2-methylthiopropionate which is useful as a pharmaceutically active compound.

The present invention relates to a process for preparation of a compound of formula I wherein

Synthesis of GlyT-1 inhibitors

The invention is concerned with (S)-1-{[2-(5-Methyl-2-phenyl-oxazol-4-yl)-ethylamino]-acetyl}-pyrrolidine-2-carbonitrile mesylate and crystalline polymorphs of this compound. This compound and its polymorphic forms exhibits superior properties compared to the previously known compounds and can be used as medicament for the treatment of disorders which are associated with DPP-IV.

Salt and polymorphs of a DPPIV inhibitor

A novel process for the preparation of compounds of formula I and optionally converting a compound of formula I into a pharmaceutically acceptable salt is disclosed. The compounds of formula I and the corresponding salts, e.g. the sodium salts, are pharmaceutically active substances. Processes for the creation of intermediates are also disclosed.

Process for the preparation of the insulin sensitizer

The present invention provides a process for preparing of d,l-&agr;-tocopherol by the catalyzed condensation of trimethylhydroquinone with isophytol. This process includes carrying out the condensation in the presence of bis-(trifluoromethylsulphonyl)amine &lsqb;HN(SO CF ) &rsqb; or a metal salt thereof of the formula Met (N(SO CF ) ) (I) as the catalyst and supercritical carbon dioxide or nitrous oxide as the solvent, wherein Met is a metal atom such as for example boron, magnesium, aluminum, silicon, scandium, titanium, vanadium, manganese, iron, cobalt, nickel, copper, zinc, yttrium, zirconium, rhodium, palladium, silver, tin, lanthanum, cerium, neodymium, praseodymium, europium, dysprosium, ytterbium, hafnium, platinum and gold, and n is the corresponding valency (1, 2, 3, or 4) of the metal atom Met. A cosolvent may also be used, which is a lower aliphatic alkanol, ketone or hydrocarbon. The product of the process is the most active member of the vitamin E group.

Preparation of d,1-&agr;-tocopherol

A process for the racemization of atropisomeric bis(phosphine oxide) compounds of formula I:

Racemization of atropisomeric bis(phosphine oxide) compounds

The invention is concerned with a process for making a compound of formula ##STR1## wherein R.sup.1 is hydrogen, alkyl, cyclo-alkyl, alkenyl, aryl or an amino protecting group; and

Process for making 3-amino-pyrolidine derivatives

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Basel, Switzerland

Shaoning Wang