Theravance Biopharma R&d IP, LLC

Alza Corporation

Nanjing University

Nanjing Effect Pharm Drug Development Corporation

Shaoling Li

Venkat R Thalladi

Hao Zhang

Manshiu Leung

Yun Mo

Robert M Gale

Patrick S L Wong

Liang-Chang Dong

Padmaja Shivanand

William W Van Osdol

Subramanian S Venkatraman

Yan Zhu

Jane Stepic

Guangming Gong

Xiaolei Tang

Yiqiao Hu

Chunhui Tong

Jinhui Wu

Dawei Ding

The invention provides a solid composition of the peripheral mu opioid antagonist axelopran and a combination dosage form of the mu opioid antagonist axelopran sulfate in an immediate release form and an opioid analgesic agent which may be in an extended release, sustained release, modified release, or controlled release form and methods of preparing such a combination dosage form.

Combination dosage form of a mu opioid receptor antagonist and an opioid agent

The present invention provides preparation methods of protein nanoparticles for in vivo delivery of pharmacologically active agents, wherein said methods are to encase pharmaceutically active agents into proteins or peptides to form nanoparticles by unfolding the protein, and subsequently refolding or assembling the protein to produce a pharmacologically active agent encased within a protein nanoparticle.

Methods for drug delivery comprising unfolding and folding proteins and peptide nanoparticles

The present invention includes an expandable osmotic layer and a coating suspension for providing an expandable osmotic layer, both of which are useful for the manufacture of controlled release dosage forms. The expandable osmotic layer of the present invention may be produced using the coating suspension of the present invention. Advantageously, the coating suspension of the present invention can be used to coat expandable osmotic layers under both wet and dry process conditions without sacrificing the quality of the expandable osmotic layers produced, and therefore provides a relatively robust coating suspension that facilitates commercial production of controlled release dosage forms including a coated expandable osmotic layer.

Expandable osmotic composition and coating suspension

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Sunnyvale, CA, United States of America

Shaoling Li