The University of Texas System

Other

Northwestern University

Shaoling Huang

David D Mcpherson

Christy Holland

Melvin E Klegerman

Susan T Laing

Robert C MacDonald

Patrick Kee

We disclose a composition comprising an echogenic liposome (ELIP) having an exterior surface, an interior surface, and at least one bilayer comprising at least one lipid selected from the group consisting of saturated phospholipids, unsaturated phospholipids, mixed phospholipids, and cholesterol, and a thrombolytic compound trapped by the ELIP. We also disclose a method of treating a medical condition in a patient characterized by a thrombus in the patient's vasculature, comprising administering to the patient the composition in an amount effective to reduce the size of the thrombus.

Echogenic vehicle for clinical delivery of plasminogen activator and other fibrin-binding therapeutics to thrombi

The present invention provides gas-containing liposomes. In particular, the present invention provide methods of generating gas-containing liposomes where the gas is introduced under pressure, as well as gas-containing liposomes which contain a large volume of gas (e.g., 10 ul of gas per 5 mg of gas-containing liposomes). In certain embodiments, the gas-containing liposomes contain nitric oxide gas. In some embodiments, such nitric oxide containing liposomes are used to treat a medical condition that is treatable by nitric oxide gas (e.g., intimal hyperplasia).

Gas-containing liposomes

Growing community of inventors

Houston, TX, United States of America

Shaoling Huang