Shaanxi Panlong Pharmaceutical Co., Ltd.

Shaanxi University of Science and Technology

Xixian New District Fenghou Original Pharmaceutical Technology Co., Ltd.

Shaojun Zhang

Chengyuan Liang

Lei Tian

Jingyi Li

Liang Xin

Xiaolin Xie

Dezhu Zhang

Xuhua Zhou

Zhao Ma

Kangxiong Wu

Juan Xia

Xiuding Yang

Han Li

Xuechuan Wang

Taotao Qiang

Nan Qin

Zhenfeng Shi

Yuting Liu

Qingbo Zhao

Min Li

Catherine J Lee

Maggie Lewis

Sundian Liu

Qianqian Zhao

Jie Zhang

Yuqing Zhao

Boyang Li

The present invention relates to the technical field of medicinal chemistry, and particularly to a method for preparing a 3-tetrazolylmethyl-1,3,5-triazin-2,4-dione compound inhibiting coronavirus 3CL protease activity and use thereof. Specifically, a compound of Formula I, or a pharmaceutically acceptable salt, or an optical isomer, or an isotope-substituted form thereof is provided. The compound effectively inhibits the SARS-CoV-2 3CLactivity, and is useful in the preparation of a SARS-CoV-2 3CLinhibitor to block the replication and transcription of SARS-CoV-2 viruses in patients. The compound prepared in the present invention has high in-vitro safety, and very good prospect of application in the preparation of SARS-CoV-2 3CLinhibitors and anti-SARS-CoV-2 drugs.

3-tetrazolylmethyl-1,3,5-triazin-2,4-dione compound inhibiting coronavirus 3CL protease activity and preparation method and use thereof

A pleuromutilin cinnamic acid ester compound with activities against antibiotic-resistant infections having the following formula (I) R, R, R, Rand Rare independently hydrogen, halogen, nitro, cyano, methoxy, trifluoromethyl, benzyloxy, aryl or dimethylamino.

Pleuromutilin cinnamic acid ester compounds with activities against antibiotic-resistant infections

Disclosed is a compound of formula I, a pharmaceutically acceptable salt, or a tautomer thereof. formula I. R, R, Rand Rare independently selected from the group consisting of hydrogen, methyl group, tert-butyl group, methoxy group, difluoromethyl, trifluoromethyl, trifluoromethoxy, nitro, halogen, phenyl and aromatic heterocyclic; Ris a hydrogen or halogen; and Ris hydrogen, C1-4 alkane or C1-4 cycloalkane.

3-triazolyl methyl-1,3,5-triazine-2,4-dione compounds and preparation method and application thereof

A compound of formula I or formula II, a pharmaceutically acceptable salt, or a tautomer thereof is disclosed. The Linker is or and n is 1-6.

Protacs targeting coronavirus 3CL protease and preparation method and application thereof

A compound of formula I or formula II, a pharmaceutically acceptable salt, or a tautomer thereof is disclosed. In formula I and II, n is 1-6.

Protacs based on VHL ligand targeting coronavirus 3CL protease and preparation method and application thereof

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Xi'an, China

Shaojun Zhang