North & South Brother Pharmacy Investment Company Limited

Sunshine Lake Pharma Co., Ltd.

Shaohui Xiong

Yingjun Zhang

Xiaojun Wang

Jiancun Zhang

Xinye Yang

Shengtian Cao

Junwen Wu

Chuanwen Yang

Shengqiang Pan

Changwei Huang

Pingjian Zhou

A nitrogen-containing tricyclic compound which acts as modulator of FXR, or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a hydrate, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof, and the use of the compound for the treatment of disease and/or condition mediated by FXR are described. And a pharmaceutical composition containing the compound disclosed herein and a method of treatment of disease and/or condition mediated by FXR comprising administering the compound or the pharmaceutical composition thereof are also described.

Nitrogen-containing tricyclic compounds and uses thereof in medicine

The invention relates to capthepsin K inhibitors and uses thereof, specifically relates to a class of compounds having the formula (I) which are used for treating or preventing cathepsin dependent diseases or conditions, specifically, wherein the cathepsin is capthepsin K. The compounds and compositions thereof can be used as bone resorption inhibitors for the treatment of associated diseases. 

Cathepsin K inhibitors and application thereof

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Dongguan, China

Shaohui Xiong