Canaan Creative Co., Ltd.

Hinova Pharmaceuticals Inc.

Xinjiang Goldwind Science & Technology Co., Ltd.

Baidu Online Network Technology (beijing) Co., Ltd.

Beijing Baidu Netcom Science and Technology Co., Ltd.

Apollo Intelligent Driving Technology (beijing) Co., Ltd.

Beijing Scitech-mq Pharmaceuticals Limited

Goldwind Science & Technology Co., Ltd.

Shaohua Zhang

Nangeng Zhang

Yuanwei Chen

Xinghai Li

Tongchuan Luo

Kexin Xu

Lei Fan

Ke Chen

Peng Yun

Mingwei Wang

Xiaoquan Wu

Xin Chen

Jie Zhou

Huan Yang

Yuanyan Huang

Yongxu Huo

Fei Wang

Qiang Zhang

Wu Du

Yansheng Liu

Chenming Hu

Xingfu Li

Chengzhi Qin

Zhilin Tu

Chengzhi Zhang

An EP300/CBP inhibitor, specifically provided is a compound as shown in formula I, or a deuterated product thereof, or a salt thereof, or a conformational isomer thereof, or a crystal form thereof, or a solvate thereof. The compound is highly selective for EP300/CBP, and can effectively inhibit the activity of EP300/CBP; in addition, the compound has an excellent inhibitory effect on various tumor cells including prostate cancer cells, leukemia cells, breast cancer cells and multiple myeloma cells. The compound has broad application prospects in the preparation of an EP300/CBP inhibitor, and drugs for preventing and/or treating tumors, myeloid hematopoietic stem/progenitor cells malignant disease, and regulating regulatory T cells.

EP300/CBP inhibitor

Circuit board with heat sink

Provided are an acylamino bridged heterocyclic compound of formula (I) or a pharmaceutically acceptable salt, an isomer, a solvate, a crystal, or a prodrug thereof, and a pharmaceutical composition comprising the compound, and an application of the compound or composition in drug preparation. The compound and the pharmaceutically acceptable salt, the isomer, the solvate, the crystal, or the prodrug thereof and the like can be used for treatment or prevention of autoimmune diseases, tumors, and neurodegenerative diseases related to receptor-interacting protein kinase-1 (RIPK1).

Acylamino bridged heterocyclic compound, and composition and application thereof

Calculating equipment

The compound of formula (I) has a good inhibitory effect on the proliferation of human prostate cancer cells CWR22RV1 and breast cancer cells; and combined use of the compound with an androgen receptor inhibitor HC-1119 significantly enhances the inhibitory effect on prostate cancer cells, and the inhibitory effect increases with increased concentration. The compound of formula (I) can not only be used independently to prepare an antineoplastic agent but can also be used in combination with other agents having antineoplastic effects, such as an androgen receptor inhibitor, or other targeting drugs etc., to prepare an antineoplastic agent having stronger therapeutic effects, especially an agent for treating prostate cancer and breast cancer.

BRD4 inhibitor as well as a preparative method and use thereof

The present application provides a method and a system for controlling continuous low voltage ride-through and high voltage ride-through of a permanent magnet direct-driven wind turbine. The method includes: determining a transient time period during which the wind turbine is transitioned from a low voltage ride-through state to a high voltage ride-through state; controlling the wind turbine to provide, during the transient time period, a gradually increasing active current to the point of common coupling; and controlling the wind turbine to provide, during the transient time period, a reactive current to the point of common coupling according to an operation state of the wind turbine before the low voltage ride-through state.

High-low voltage continuous ride-through control method and system for permanent magnet direct-drive wind power generating set

The present application provides a method and a system for controlling continuous high voltage ride-through and low voltage ride-through of a permanent magnet direct-driven wind turbine. The method includes: determining a transient time period during which the wind turbine is transitioned from a high voltage ride-through state to a low voltage ride-through state; controlling the wind turbine to provide, during the transient time period, a gradually increasing active current to the point of common coupling; and controlling the wind turbine to provide, during the transient time period, a reactive current to the point of common coupling according to an operation state of the wind turbine before the high voltage ride-through state.

Control method and system for continuous high and low voltage ride through of permanent-magnet direct-drive wind-driven generator set

Disclosed is a BRD4 inhibitor as shown in formula I, belonging to the field of compound drugs. The compound provided has a good inhibitory effect on prostate cancer cell proliferation, and can be used for preparing a drug combatting tumors, autoimmune or inflammatory diseases and viral infection, and in particular an anti-prostate cancer drug. 

BRD4 inhibitor

A method, apparatus and device for storing vehicular data. An embodiment of a method for storing vehicular data includes: analyzing importance of received vehicular data to determine a storage level of the vehicular data; acquiring a corresponding key and a corresponding encryption algorithm based on the storage level of the vehicular data; encrypting the vehicular data using the acquired key and the acquired encryption algorithm; and storing encrypted vehicular data in a storage area corresponding to the storage level of the vehicular data. The embodiment may improve the safety of vehicular data by encrypted storage of the data in different levels, effectively prevent important vehicular data from being illegally read or maliciously falsified, and improve the storage efficiency of the vehicular data.

Method, apparatus and device for storing vehicular data

A method and apparatus for acquiring vehicular data. An embodiment of the method includes: acquiring vehicular data of an autonomous vehicle equipped with a vehicular data acquisition device by the vehicular data acquisition device, the vehicular data comprising: a control instruction of the autonomous vehicle and sensor data from a sensor on the autonomous vehicle; encrypting the vehicular data to obtain encrypted vehicular data, and storing the encrypted vehicular data; receiving a request for acquiring vehicular data sent by a server; and sending the encrypted vehicular data to the server when the vehicle identifier is identical to a vehicle identifier of the autonomous vehicle and the device identifier is identical to a device identifier of the vehicular data acquisition device.

Method and apparatus for acquiring vehicular data

The objective of the present disclosure is to provide a method and device for communicating securely between a T-Box device and an ECU device in an Internet of Vehicles system. Specifically, sending, by a T-Box device, a first piece of information to a corresponding ECU device; generating, by the ECU device, a second piece of information; generating, by the T-Box device, a third piece of information; generating, by the T-Box device, a first key; encrypting, by the T-Box device, a to-be-issued instruction based on the first key; generating, by the ECU device, a second key; and decrypting, by the ECU device, the encrypted instruction based on the second key to obtain the instruction. Compared with the prior art, the present disclosure achieves the secure communication between the T-Box device and the ECU device.

Method and device for communicating securely between T-box device and ECU device in internet of vehicles system

Quinoline compounds and salts, hydrates or solvates serving as a selective uric acid reabsorption inhibitor, can be used in the treatment of hyperuricemia and gout by promoting uric acid to excrete from the body and reducing serum uric acid. Such compounds have the effect of reducing the uric acid in the animal body and human body.

Quinoline compounds, preparation methods thereof, and uses thereof as urate transporter inhibitor drug

Growing community of inventors

Beijing, China

Shaohua Zhang