Southeast University

Nanjing Medical University

Zhejiang Shapuaisi Pharmacy Ltd.

Shaohua Gou

Hong Shen

Yindi Zhang

Jianping Shen

Yanqin Zhu

Luzhong Feng

Jianwei Wu

Dekang Chen

Wanxiang Yang

Disclosed is NO donor compound and preparation method, pharmaceutical composition, and use. The compound has a structure represented by formula The NO donor compound and the pharmaceutical composition thereof, as hypoxia-activated NO donors, may be prepared as drugs for treating myocardial hypoxic damage disease. The prepared drugs can exert efficacy at both the cellular level and the animal level, and the synthesis method of the compound is simple and easy to operate.

NO donor compound, preparation method thereof, pharmaceutical composition comprising same, and use thereof

Platinum complexes containing 3-ketone cyclobutane 1,1-dicarboxylic acid as leaving group for treating cancers and a preparation method of the complexes, one of the platinum complexes is cis-[3-ketone cyclobutane-1,1-dicarboxylic acid radical.diamineplatinum (II)], GSH-5 for short, the chemical structure formula is expressed by formula (1). The other platinum complex is cis-[3-ketone-cyclobutane-1,1-dicarboxylic acid radical.trans-1,2-cyclohexanediamineplatinum (II)], GSH-6 for short, the chemical structure formula is expressed by formula (2). In the formula (2), two chiral carbon atoms marked with * in the trans-1,2-cyclohexanediamine group are both of R forms or S forms.

Anti-tumor bivalent platinum complex and preparation method for complex and ligand of complex

Organic dicarboxylic acid compounds, salts and preparation methods thereof are described. The compounds have activity of resisting oxidation damage to crystalline lens of eyes. The structures of the above organic dicarboxylic acid compounds are shown as wherein R is a hydrogen atom, a Calkyl group, a Calkoxyl group, or a halogen atom.

Organic dicarboxylic acids, salts and preparation method thereof

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Jiangsu, China

Shaohua Gou