Qilu Pharmaceutical Co., Ltd.

Shaobo Yang

Jingyi Wang

Long Zhang

Jianrong Zhu

Zongru Guo

Minghui Zhang

Chuanwen Fan

Qingmin Yang

Shousheng Yan

Zhongru Guo

Ying Li

The present invention relates to 4-(substituted anilino)-quinazoline derivatives as tyrosine kinase inhibitors. Specifically, compounds of formula I, or pharmaceutically acceptable salts or solvates thereof are disclosed, in which each substitutent in formula I is defined in the description. Preparation method of the compounds of formula I, pharmaceutical compositions and pharmaceutical uses thereof are also disclosed. The compounds of formula I are effective tyrosine kinase inhibitors. 

4-(substituted anilino)-quinazoline derivatives useful as tyrosine kinase inhibitors

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Shandong, China

Shaobo Yang