Isk Americas Incorporated

Ishihara Sangyo Kaisha, Ltd.

Roche Palo Alto LLC

Shao-Yong Wu

Masamitsu Tsukamoto

Bai-Ping Ying

Sandeep Gupta

David A Pulman

Takahiro Haga

Hiroshi Shimoharada

David Michael Goldstein

James Patrick Dunn

Alam Jahangir

Leyi Gong

Wylie Solang Palmer

Humberto Bartolome Arzeno

Joan Heather Hogg

Xiaochun Han

Tania M Silva

Teresa Alejandra Trejo-Martin

Deborah Carol Reuter

Parcharee Tivitmahaisoon

Mohammand R Masjedizadeh

The invention relates to prodrugs of JNK inhibitors and corresponding methods, formulations, and compositions for inhibiting JNK and treating JNK-mediated disorders. The application discloses prodrugs of JNK inhibitors, as described below in formula I: wherein m, n, p, q, Q, r, R, R, R, X, X, X, X, X, X, Y, Y, Zand Zare as defined herein. The compounds and compositions disclosed herein are useful to modulate the activity of JNK and treat diseases associated with JNK activity. Disclosed are methods and formulations for inhibiting JNK and treating JNK-mediated disorders, and the like, with the compounds, and processes for making said compounds, and corresponding compositions, disclosed herein.

Inhibitors of JNK

Methods for preparing tritium or deuterium labeled thiorphan comprising reacting a compound of formula j wherein m is from 1 to 5 and X is halo, with Zwherein Z is tritium or deuterium, in the presence of a catalyst, to form a compound of formula k wherein n is from 1 to 5, provided that n is less than or equal to m.

Process for synthesis of tritiated and deuterated thiorphan and acetorphan

Novel herbicidal and defoliant substituted aniline derived compounds represented by general structure (I)are described. W, X, Y, Z, and Q are as defined in the disclosure. Also described are the processes for the manufacture of these compounds and agriculturally suitable compositions containing these as active ingredients which are useful as herbicides for general or selective pre-emergent or post-emergent control of undesired plant species and defoliants at very low concentrations of these biologically active compounds.

Substituted benzene compounds, process for their preparation, and herbicidal and defoliant compositions containing them

Fused-benzene derivatives useful as herbicides

Novel herbicidal and defoliant substituted aniline derived compounds represented by general structure (I) are described. W, X, Y, Z, and Q are as defined in the disclosure. Also described are the processes for the manufacture of these compounds and agriculturally suitable compositions containing these as active ingredients which are useful as herbicides for general or selective pre-emergent or post-emergent control of undesired plant species and defoliants at very low concentrations of these biologically active compounds.

Diaryl ethers and processes for their preparation and herbicidal and desiccant compositions containing them

Diaryl ether compounds useful in the control of weeds are described. An exemplary compound is represented by the general formula (I):

A compound represented by the formula (I) or its salt and herbicidal and desiccant use thereof:

Novel fused heterocycle compounds represented by the formula (I) are described. Q, R, W, &mdash;L&mdash;X&mdash;, Y, Z, and n are as defined in the disclosure. Also described are the processes for the manufacture of these compounds and agriculturally suitable compositions containing these as active ingredients which are useful as herbicides for general or selective pre-emergent or post-emergent control of undesired plant species.

Fused heterocycle compounds, process for their preparation, and herbicidal compositions containing them

A compound represented by the formula (I) or its salt and herbicidal and desiccant use thereof: ##STR1## wherein X, Y are independently hydrogen, halogen, cyano, nitro, or (C.sub.1-6)haloalkyl;

Growing community of inventors

Fremont, CA, United States of America

Shao-Yong Wu