Industrial Technology Research Institute

Shao-Jen Yeh

Chin-Fu Chen

Ya-Jen Yu

Tsai-Yu Lin

Shian-Yih Wang

Rung-Jiun Gau

Po-Liang Lai

Yu-Shih Weng

Ming-Cheng Shih

The disclosed is a biodegradable copolymer, an amphiphilic diblock copolymer, composed of a hydrophilic segment and a hydrophobic segment. The hydrophilic segment is an endcapped PEG or derivatives thereof. The hydrophilic segment is a random polymer polymerized of lactone or cyclic C-Cmolecule and lactic acid/glycolic acid. There is no coupling agent between the hydrophilic and hydrophobic segments, and the biodegradable copolymer is formed by one-pot ring-opening polymerization. The biodegradable copolymer can be dissolved in water to form a thermosensitive material having a phase transfer temperature of 25 to 50&#xb0; C., thereby being applied to biological activity factor delivery, tissue engineering, cell culture and biological glue.

Biodegradable copolymer and thermosensitive material

A cell culture apparatus and a method for fabricating the cell culture apparatus are disclosed, the method comprises forming at least one fillister on a biomaterial composite layer by photolithography, wherein the biomaterial composite layer contains two gel materials. One is a bio-compatible hydrogel composition having various weight ratio of: 2-hydroxyethylmathacrylate (HEMA), bisphenol A and glycidyl methacrylate (bis-GMA), triethylene glycol dimethacrylate (TEGDMA), r-methacryloxypropyl trimethoxysilane (MAPTMS), &#x3b1;,&#x3b1;-diethoxyacetophenone (DEAP), and the other one is a photo-sensitive silica gel composition.

Cell culture apparatus and method of fabricating the apparatus

A cell culture apparatus and a method for fabricating the cell culture apparatus are disclosed, the method comprises forming at least one fillister on a biomaterial composite layer by photolithography, wherein the biomaterial composite layer contains two gel materials. One is a bio-compatible hydrogel composition having various weight ratio of: 2-hydroxyethylmathacrylate (HEMA), bisphenolA and glycidyl methacrylate (bis-GMA), triethylene glycol dimethacrylate (TEGDMA), r-methacryloxypropyl trimethoxysilane (MAPTMS), &#x3b1;,&#x3b1;-diethoxyacetophenone (DEAP), and the other one is a photo-sensitive silica gel composition.

Hydrogel composition for cell culture apparatus

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Jhongpu, Taiwan

Shao-Jen Yeh