Entasis Therapeutics, Inc.

Astrazeneca Ab

Shanta Bist

Neil Bifulco

Bolin Geng

Hoan Huynh

Thomas Francois Durand-Reville

Janelle Comita-Prevoir

Brendan Chen

Satenig Guler

Hui Xiong

Liang Zhao

Ye Wu

Daemian Dussault

Brian A Sherer

Gregory Steven Basarab

John Irvin Manchester

Helen Mcguire

Helen McGuire

The present invention is directed to compounds which are beta-lacatamase inhibitors. The compounds and their pharmaceutically acceptable salts, are useful in combination with beta-lactam antibiotics, or alone, for the treatment of bacterial infections, including infections caused by drug resistant organisms, including multi-drug resistant organisms. The present invention includes compounds according to formula (Ia): or a pharmaceutically acceptable salt thereof, wherein the values of R, R, Rand Rare described herein.

&#x3b2;-lactamase inhibitor compounds

Beta-lactamase inhibitor compounds

Compounds of formula (I) and their pharmaceutically acceptable salts are described. Processes for their preparation, pharmaceutical compositions containing them, their use as medicaments and their use in the treatment of bacterial infections are also described. 

Alkyl urea substituted pyridines

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Waltham, MA, United States of America

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