Bristol-myers Squibb Compnay

Skinmedica, Inc.

Women First Healthcare, Inc.

Shannon X Zhao

Jingyang Zhu

Purushotham Vemishetti

Carrie A Costello

Scott T Chadwick

Benjamin A Price

Paul M Skonezny

Li You

Brenda Joyce White

Provided is a method of resolving a racemic mixture of a compound of formula I to obtain a desired enantiomer: wherein Ar is Cor Caromatic group that can be substituted with H, Cto Calkyl, trifluoromethyl or halo, Ris halo or &#x2014;S&#x2014;R, wherein Ris H or acetyl, and Ris H or Cto Calkyl, the method comprising: reacting a compound of formula I wherein the compound is an ester whereby Ris Cto Calkyl with a lipase derived fromto stereoselectively hydrolyze the ester bond to produce an acid; and isolating the acid, wherein the reaction is conducted in a solvent comprising 80% to 98% v/v % organic phase and a residue of water phase (which can be buffered).

Enzymatic resolution of aryl and thio-substituted acids

Provided are processes and synthetic intermediates useful for the preparation of &#x3b1;-difluoromethylornithine (DFMO) having the formula

Processes for the production of &#x3b1;-difluoromethyl ornithine (DFMO)

Provided are processes and synthetic intermediates useful for the preparation of &agr;-difluoromethylornithine (DFMO) having the formula

Processes for the production of &agr;-difluoromethyl ornithine (DFMO)

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East Syracuse, NY, United States of America

Shannon X Zhao