Genentech, Inc.

F. Hoffmann-La Roche Ag

Shannon Turley

Sanjeev Mariathasan

Priti Hegde

Yulei Wang

Luciana Molinero

Yinghui Guan

Yasin Senbabaoglu

Jillian Astarita

Yagai Yang

The present invention provides diagnostic methods, therapeutic methods, and compositions for the treatment of cancer (e.g., a bladder cancer (e.g., UC, e.g., mUC), a kidney cancer, a lung cancer, a liver cancer, an ovarian cancer, a pancreatic cancer, a colorectal cancer, or a breast cancer). The invention is based, at least in part, on the discovery that expression levels of one or more biomarkers described herein in a sample from an individual having cancer can be used in methods of identifying an individual having a cancer who may benefit with an anti-cancer therapy that includes an immunotherapy (e.g., a PD-L1 axis binding antagonist such as an anti-PD-L1 antibody (e.g., atezolizumab)) and a suppressive stromal antagonist (e.g., a TGF-&#x3b2; antagonist), methods for selecting a therapy for an individual having cancer, methods of treating an individual having cancer, methods for assessing a response or monitoring the response of an individual to treatment with an anti-cancer therapy that includes an immunotherapy (e.g., a PD-L1 axis binding antagonist such as an anti-PD-L1 antibody (e.g., atezolizumab)) and a suppressive stromal antagonist (e.g., a TGF-&#x3b2; antagonist), and related kits, anti-cancer therapies, and uses.

Diagnostic and therapeutic methods for cancer

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San Anselmo, CA, United States of America

Shannon Turley