Humacyte, Inc

Yale University

Other

Shannon Dahl

Laura E Niklason

Angela Huang

Liping Zhao

Justin T Strader

Juliana Blum

Parrish M Galliher

Michael Edward Fisher

Colin R Tuohey

Patrick M Guertin

Joseph D Crowell

William E Tente

Heather L Prichard

Geoffrey Erickson

Frank Zeigler

George C Engelmayr, Jr

Jinlin Zhang

Stuart Irwin

Yuling Li

Tubular prostheses are provided for use in airways, upper digestive, and urinary tracts. Each of these uses has its own specific sets of biological specifications, based on what it must contain and exclude and the physical and chemical pressures and stresses to which it is subjected. The prostheses may be made from allogeneic cells. Thus they can be manufactured and stored prior to an individual's personal need arising.

Tubular prostheses

Embodiments of the present disclosure are directed to apparatuses and methods for fabricating tubular structures from a combination of fibrous materials for use in, for example, tissue engineering scaffold applications. These materials may also be useful in other biological or non-biological applications in which such tubular fibrous structures may be applicable, examples including conventional medical devices, filters, fiber optics, cable wraps, geotextiles, batteries, fuel cells, armor, and other diverse applications.

Methods and apparatuses for forming fibrous tubes

A single-use, single or multiple tissue, organ, and graft bioreactor and environmental control system is designed to replicate the necessary conditions for growth of tissues, organs, or grafts, while addressing problems in scaling up the tissue growth; adaptation to a single-use or disposable format; and operation as a stand-alone unit that provides full environmental control of cell culture conditions.

Tissue and organ graft bioreactor and method of operation

The present invention provides compositions comprising isolated human collagen, isolated human elastin and a pharmaceutically acceptable carrier wherein the human elastin is substantially insoluble in water with a molecular weight greater than 100 kDa. The present invention further provides methods and kits for soft tissue augmentation.

Compositions and methods for soft tissue augmentation

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Durham, NC, United States of America

Shannon Dahl