Mylan Laboratories Limited

Shankar Rama

Lakshmana Rao Vadali

Srinivasa Rao Dasari

Ramesh Dandala

Debashish Datta

Arabinda Sahu

Siva Rama Prasad Vellanki

Srikanth Sarat Chandra Gorantla

Seshadri Rao Manukonda

Raja Babu Balusu

Nagaraju Mittapelly

Mastan Rao Ravi

Hari Babu Nandipati

Seshari Rao Manukonda

Vijay Kumar Palla

Rao Potla Srinivasa

Krishna Ravi Vijaya

Srinivasa Rao Dasarl

Rao Manukonda Seshadri

The present invention relates to an improved process for the preparation of pure compound of Formula-II, which is an intermediate in the preparation of Aliskiren and further conversion of compound of Formula-II into Aliskiren or its pharmaceutically acceptable salts. 

Process for the preparation of aliskiren

The present invention relates to an improved process for the preparation of Tenofovir Disoproxil and its pharmaceutically acceptable salts comprising the steps of: a) esterifying Tenofovir with chloromethyl isopropyl carbonate in presence of a base, phase transfer catalyst and optionally dehydrating agent, in a suitable solvent; b) optionally purifying Tenofovir Disoproxil; and c) converting of Tenofovir Disoproxil into its pharmaceutically acceptable salts. The present invention further relates to a process for the preparation of Tenofovir by reacting 1-(6-amino-purin-9-yl)-propan-2-ol with toluene-4-sulfonic acid diethoxy phosphoryl methyl ester in presence of a base in a non-polar solvent medium followed by hydrolysis.

Process for the preparation of tenofovir disoproxil fumarate

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Hyderabad Telangana, India

Shankar Rama