Pfizer Corporation

Other

Rensselaer Polytechnic Institute

Shanghui Hu

Junhua Tao

Carlos Alberto Martinez

Patrick Kelleher

Yves Dumond

William Eugene Tully

Padraig M O'Neill

David W Bauer

Timothy J Watson

Jonathan S Dordick

Lucy Xiumin Zhao

Steven M Cramer

Kaushal Rege

Xufang Tian

Jinying Ning

The present invention provides a family of novel cytotoxic pentapeptides, which show potent antitumor activities against several cancer lines. The antibody-drug conjugates prepared from those pentapeptides can efficiently kill cancer cells.

Potent and efficient cytotoxic peptides and antibody-drug conjugates thereof and their synthesis

The present invention is directed to a 2-deoxyribose-5-phosphate aldolase (DERA) chemoenzymatic process for making chiral compounds.

Process for preparing chiral compounds

Materials and methods for preparing (S)-(+)-3-aminomethyl-5-methyl-hexanoic acid and structurally related compounds via enzymatic kinetic resolution are disclosed.

Preparation of pregabalin and related compounds

Materials and Methods for preparing (S)-(+)-3-aminomethyl-5-methyl-hexanoic acid and structurally related compounds via enzymatic kinetic resolution are disclosed.

Aminoglycoside-polyamines are disclosed along with methods of use thereof in displacement chromatography and as DNA-binding ligands. The aminoglycoside-polyamines are derivatives of carbohydrates, such as sugars, amino sugars, deoxysugars, glycosides, nucleosides and their substituted counterparts. The subject polyamines possess a group in place of at least one hydrogen atom of at least one hydroxyl group of the carbohydrate compound. In these compounds Ris an alkyl group or an azaalkyl group, and Ris a primary or secondary amino group.

Aminoglycoside-polyamine displacers and methods of use in displacement chromatography

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San Diego, CA, United States of America

Shanghui Hu