Jiangsu Hengrui Medicine Company Ltd.

Shanghai Hengrui Pharmaceutical Co., Ltd.

Shanghai Meiyue Biotech Development Co., Ltd.

Shanghai Yu

Fanglong Yang

Jingjing Yan

Lei Chen

Mingxun He

Xiqian Zhang

Zhichao Xie

Lingxiang Chen

Feng He

Weikang Tao

Yan Feng

Chaodong Wang

Xiao Wu

Xiaolin Wang

Qian He

Zhilong Hu

Shiqiang Li

Feihong Dai

Yawen Ding

A quaternary lactam compound of formula (I). The compound is used in the manufacture of a medicament for the treatment and/or prevention of thrombotic or thromboembolic disorders. 

Quaternary lactam compound and pharmaceutical use thereof

The present invention relates to a five-membered heteroaryl ring bridged ring derivative, a preparation method therefor and the medical use thereof. In particular, the present invention relates to a new five-membered heteroaryl ring bridged ring derivative as shown in formula (I), a preparation method therefor and a pharmaceutical composition comprising the derivative, and the use thereof as a therapeutic agent, in particular as a TGF-&#x3b2; inhibitor, and the use in the preparation of a drug for treating, preventing or reducing cancers mediated by the over-expression of TGF-&#x3b2;, wherein the definition of each substituent in the general formula (I) is the same as defined in the description. 

Five-membered heteroaryl ring bridged ring derivative, preparation method therefor and medical use thereof

The present invention relates to a piperidine derivative and the preparation method and a pharmaceutical use thereof. In particular, the present invention relates to the piperidine derivative as shown by general formula (I) and the preparation method thereof and a pharmaceutical composition containing the same, and the use thereof as an estrogen receptor modulator in the treatment of estrogen receptor mediated or dependent diseases or conditions, the diseases preferably being breast cancer. In the abstract, the definition of each substituent of the general formula (I) is the same as that in the description. 

Piperidine derivative and preparation method and pharmaceutical use thereof

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Shanghai Yu