Dexcom, Inc.

The Polymer Technology Group, Incorporated

Shanger Wang

Ted Tang Lee

Peter C Simpson

Jennifer Blackwell

Jiong Zou

Sean T Saint

Sebastian Bohm

Disha B Sheth

Jason Mitchell

Neel Narayan Shah

Jack Pryor

Paul V Neale

Ryan Everett Schoonmaker

Jason M Halac

John Michael Gray

Robert S Ward

Daiting Rong

Michael J Estes

Jeff Jackson

Maria Noel Brown Wells

Todd Andrew Newhouse

Robert James Boock

Robert L Jones

Mark Allan Tapsak

Stephen J Vanslyke

Anna Leigh Davis

Sebastian Böhm

Minglian Shi

Michael Levozier Moore

John Patrick Majewski

Huashi Zhang

Jonathan Hughes

Rui Ma

Leah Morta Edra

Andrew Trinin Dennis

Xuwei Jiang

Jeff T Suri

Liang Wang

Wenjie Lan

David Sze

Devon M Headen

Maria Neol Brown Wells

Yuan Tian

Keith Mccrea

James Parakka

James P Parakka

Scott Curtin

Li Li

Keith R Mccrea

Disclosed are devices for determining an analyte concentration. The devices comprise a sensor configured to generate a signal associated with a concentration of an analyte and an electronics unit operatively connected to the sensor. The electronics unit may be engaged with a housing that may secure the device to a host's skin. In this regard, in one embodiment, the housing may be attached to an adhesive patch that is fastened to the skin of the host.

Analyte sensor

Disclosed are devices for determining an analyte concentration (e.g., glucose). The devices comprise a sensor configured to generate a signal associated with a concentration of an analyte and a sensing membrane located over the sensor. The sensing membrane comprises an enzyme layer, wherein the enzyme layer comprises an enzyme and a polymer comprising polyurethane and/or polyurea segments and one or more zwitterionic repeating units. The enzyme layer protects the enzyme and prevents it from leaching from the sensing membrane into a host or deactivating.

Enzyme immobilized adhesive layer for analyte sensors

Various examples described herein are directed to systems, apparatuses, and methods for mitigating break-in in an analyte sensor. An example analyte sensor system comprises an analyte sensor applicator comprising a needle; an analyte sensor comprising at least a working electrode and a reference electrode, the analyte sensor positioned at least partially within a lumen of the needle; and a hydrating agent positioned within the lumen of the needle to at least partially hydrate the needle.

Analyte sensor break-in mitigation

Sensor systems can be used to measure an analyte concentration. Sensor systems can include a base having a distal side configured to face towards a person's skin. An adhesive can couple the base to the skin. A transcutaneous analyte measurement sensor can be coupled to the base and can be located at least partially in the host. A transmitter can be coupled to the base and can transmit analyte measurement data to a remote device.

Transcutaneous analyte sensor systems and methods

Sensor devices including dissolvable tissue-piercing tips are provided. The sensor devices can be used in conjunction with dissolvable needles configured for inserting the sensor devices into a host. Hardening agents for strengthening membranes on sensor devices are also provided. Methods of using and fabricating sensor devices are also provided.

Sensors for continuous analyte monitoring, and related methods

Sensors for continuous analyte monitoring

Disclosed are devices for determining an analyte concentration (e.g., glucose). The devices comprise a sensor configured to generate a signal associated with a concentration of an analyte and a sensing membrane located over the sensor. The sensing membrane comprises a biointerface layer which interfaces with a biological fluid containing the analyte to be measured. The biointerface layer can comprises a biointerface polymer, wherein the biointerface polymer comprises polyurethane and/or polyurea segments and one or more zwitterionic repeating units. The sensing membrane can also comprise an enzyme layer, wherein the enzyme layer comprises an enzyme and a polymer comprising polyurethane and/or polyurea segments and one or more zwitterionic repeating units. The sensing membrane can also comprise a diffusion-resistance layer, which can comprise a base polymer having a lowest Tg of greater than &#x2212;50 C.

Membrane layers for analyte sensors

The present disclosure relates to a needle including a wall structure, a cutting edge and a blunt contour. The needle advantageously can be used to deliver a sensor (such as a glucose or other analyte sensor) through an outer skin layer and into a sensor depth in a less invasive way than prior art needles. The size of the cutting edge is balanced against a portion of the distal wall structure that has blunt contours. Thus, the needle is capable of cutting the more durable outer skin layer (first phase) and then progressively stretching open the cut for further advancement into the subcutaneous layer (second phase). When the needle is sufficiently advanced, it is retracted leaving the sensor in a desired position. Early testing has shown a reduction of 'dip and recover' from glucose sensors delivered using the needle.

Needle for transcutaneous analyte sensor delivery

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Castro Valley, CA, United States of America

Shanger Wang