Brown University

Rhode Island Hospital

Shane Lee

Wael Farouk Asaad

Peter Maxwell Lauro

Owen Leary

David D Liu

Rohan Rastogi

Daniel Esteban Amaya

Umer Akbar

Zakir Tahiry

James Young Ho Yu

Noah Trac

Minkyu Ahn

A method includes engaging Parkinson's Disease (PD) subjects in a continuous motor performance task that elicits natural motor variability, quantifying natural motor variability of each PD subject with an array of motor metrics at short timescales, applying a machine-learning classification or regression algorithm to determine weights for each of these metrics to maximally differentiate each patient's motor performance from that of controls performing the same task, and combining the weights to determine a scalar metric of motor performance for each short epoch of motor behavior.

Neural biomarkers of Parkinson's disease

A system for placement of biocompatible electrodes in an opening formed in a patient's body part, such as DBS electrodes inserted into a patient's skull during surgical procedures in the brain. The system includes a coupled catheter and annulus. The catheter includes a guide tube having at least three cooperating guide elements configured to releasably fit together and collectively form a continuous lumen through the catheter that is dimensioned to receive an electrode therein. The annulus is configured to be placed in the opening formed in the patient's body part, and to receive the catheter therethrough. A track mechanism is used to operably couple the catheter to the annulus.

Coupled annulus and catheter system for placement of biocompatible brain electrodes and like devices

A system includes intracranial electrodes embedded into a cranium, a deep brain stimulation system embedded into the cranium, a brain implantable device embedded into the cranium, and a pulse generator, the deep brain stimulation system and the brain implantable device linked to the intracranial electrodes and to the pulse generator.

Brain implantable device

Growing community of inventors

Providence, RI, United States of America

Shane Lee