Other

Guangzhou Institute of Respiratory Disease

The First Affiliated Hospital of Guangzhou Medical University

The First Affiliatted Hospital of Guangzhou Medical University

State Key Laboratory of Respiratory Disease

Shan Zhong

Kefang Lai

Bonian Zhong

Xiaodong Liu

Yichu Nie

Chuqin Huang

Nanshan Zhong

XiaoDong Liu

Zhenyong Gan

The present invention discloses antotal polysaccharide extract with antitussive activity, an extraction method thereof and an application in the preparation of a medicine for preventing and treating coughs. The present invention proves that thetotal polysaccharide extract has a significant effect of suppressing cough for the first time through a large number of pharmacodynamic tests, has the therapeutic effect approximate to codeine, has the effect of prolonging the cough latent period better than codeine, and also finds that the totalpolysaccharide extract has the effects of reducing the cough sensitivity and suppressing the airway inflammation for the first time, has excellent preventive and therapeutic effects on various types of coughs, and can be used for preparing the medicines for preventing and treating cough-related diseases.

Application of Asarum total polysaccharides in preparation of medicine for treating cough

The invention discloses a use of asarinin in preparation of medicines for treating various coughs. The asarinin is used for preparing medicines for treating various coughs separately or in combination with other medicines. The asarinin can be extracted by an SFE-CO2 method. The asarinin and usable drug carriers or excipients are made into various formulations. And the formulations are granules, tablets, capsules, soft capsules, pills, dripping pills, ointments, syrups, injection, oral liquid, tinctures, sustained-releasing drugs, controlled release drugs or targeting preparations.

Use of asarinin in preparation of medicines for treating various coughs

The invention discloses a method for extracting high-purity asarinin and use thereof. The method comprises: putting crudepowder in an SFE-COdevice; under the conditions that an extraction kettle has a pressure of 30-40 Mpa and a temperature of 45-70&#xb0; C., separating kettles I and II have a pressure of 5-10 Mpa, a temperature of 30-50&#xb0; C. and the flow rate of COis 35-60 L/h, extracting for 60-240 min to obtain total volatile oil of; standing the total volatile oil offor 24-72 h at a low temperature, and carrying out suction filtration under reduced pressure to obtain crude asarinin; and re-crystallizing the crude asarinin in absolute ethanol twice to obtain pure asarinin. It is found for the first time that asarinin has a good cough-relieving activity and thus can be used in preparing medicines for treating various types of coughs.

Method for extracting high-purity asarinin by supercritical carbon dioxide extraction method and use thereof

The present invention relates to a new application of Fructus schisandrae total polysaccharides in preparation of medicine or nutraceuticals for treating coughing, and more specifically to a new application of Fructus schisandrae total polysaccharides in preparation of medicine or nutraceuticals for preventing and relieving coughing and eliminating airway inflammation. Experiments demonstrate that the Fructus schisandrae total polysaccharides can remarkably reduce the coughing times of a guinea pig with increased cough sensitivity induced by cigarette smoke and an acute cough guinea pig induced by citric acid smoke, prolong the latent period of cough, and significantly reduce the airway inflammation of the guinea pig with increased cough susceptibility induced by cigarette smoke, so that the Fructus schisandrae total polysaccharides can be used for preparing drugs for preventing cough, relieving cough and eliminating airway inflammation.

Application of fructus schisandrae total polysaccharides in preparatoin of medicine or nutraceuticals used for treating coughing

Growing community of inventors

Guangzhou, China

Shan Zhong