Poly-med, Inc.

Ethicon, Gmbh

Clemson University

Other

Ipsen Manufacturing Ireland Limited

Kinerton Limited

Smith & Nephew Pte. Limited

United States Surgical Corporation

Biomeasure Incorporated

US Government As Represented by the Secretary of the Army

Medtronic Vascular, Inc.

Aesculap Ag

Societe De Conseils De Recherches Et D'applications Scientifiques Sas

Shalaby Wahba Shalaby

Dennis D Jamiolkowski

Rao S Bezwada

Joel Thomas Corbett

Georgios T Hilas

Shawn Peniston

Jacques-Pierre Moreau

Kenneth David Gray

Steven A Jackson

Donald F Koelmel

Kenneth W Clinkscales

Jacqueline M Allan

Hugh D Newman, Jr

Francis X Ignatious

Kimberly A Carpenter

Douglas D Greene

Jason Olbrich

Michael Scott Taylor

Michael Aaron Vaughn

David Ingram

Meng Deng

Susan L Roweton

Sheila Nagatomi

James M Lindsey

Scott Taylor

Alastair W Hunter

Thomas Ciaran Loughman

Franck Jean-Claude Touraud

Ruth M Russell

Edgar S Schipper

Todd Campbell

James M Lindsey, Iii

Helmut Goldmann

Nagabhushanam Totakura

Adel Kafrawy

Christof Merckle

Richard V Gregory

Mark T Gaterud

Bernard L Williams

Stephen C Arnold

Charles L Linden

Lance A Monroe

Francis Ignatious

Torbjorn Mathisen

M Scott Taylor

Kishore Udipi

Richard L Kronenthal

Gere S DiZerega

Peiwen Cheng

Torbjörn Mathisen

Dan Åkerfeldt

Steven C Arnold

Per Egnelöv

Frank V Mattei

Warren D Sheffield

David Wasserman

Amy L Finkenaur

Douglas B Johns

Martin Stephenson

Carl R Smith

LeRoy L Richer

Lyudmila K Kokish

Elisabeth A Sandoval

Karen R Rogers

M Aaron Vaughn

Russell A Johnson

M Scott McCaig

Hany W Demian

Theodore D Taylor

Daniel C Clupper

Fredrik Preiniz

Julie Ann Miller

Dennis D Damiolkowski

Louise Schaap

Graham H Hartley, Deceased

Bruce L Anneaux

Marc Shalaby

Waleed S W Shalaby

Su Ping Lyu

Julie Miller Hasenwinkel

David E Linden

Alice H Brandenburg

Francois K Njieha

Mo Erneta

Otis J Bouwsma

James M Lindsay, Iii

Jonathan M Cohen

Joel Corbett

Absorbable composite medical devices such as surgical meshes and braided sutures, which display two or more absorption/biodegradation and breaking strength retention profiles and exhibit unique properties in different clinical settings, are made using combinations of at least two types of yarns having distinctly different physicochemical and biological properties and incorporate in the subject construct special designs to provide a range of unique properties as clinically useful implants.

Absorbable/biodegradable composite yarn constructs and applications thereof

Absorbable barrier composites are designed for modulated gas and water permeability depending on clinical use and are formed of at least two physicochemically distinct components, one of which is a film adjoined to a knitted mesh and/or electrostatically spun, non-woven fabric. Depending on the physicochemical properties of the barrier composite, it can be used in neurological and urinogenital surgical procedures as well as tissue engineering and/or as physical barriers to prevent adhesion formation following several types of surgical procedures.

Absorbable permeability-modulated barrier composites and applications thereof

A radiation and radiochemically sterilized, multi-component, fiber-reinforced composite, absorbable/disintegratable urinogenital stent, such as an endoureteral stent, with radiomodulated residence time in the biological site of 1 to 10 weeks depending on the high energy radiation dose used for sterilization.

Radiation and radiochemically sterilized fiber-reinforced, composite urinogenital stents

Absorbable, permeability-modulated barrier composites and applications thereof

A family of selectively absorbable/biodegradable, fibrous composite constructs includes different combinations of biostable and absorbable/biodegradable yarns assembled as initially interdependent, load-bearing components, transitioning to exhibit independent functional properties during in vivo end-use. The family of constructs consists of two groups, one group is made of fiber-reinforced composites of high compliance, absorbable matrices of segmented polyaxial copolyesters reinforced with multifilament yarn constructs, which are combinations of ultrahigh molecular weight polyethylene fibers and at least one absorbable/biodegradable fiber selected from silk fibers and multifilament yarns made from linear segmented, l-lactide copolyesters and poly (3-hydroxyalkanoates, are useful in orthopedic, maxillofacial, urological, vascular, hernial repair and tissue engineering applications. The second group is made of coated and uncoated, warp-knitted mesh constructs for use in hernial, vascular, and urological tissue repair and tissue engineering.

Selectively absorbable/biodegradable fibrous composite constructs and applications thereof

Biocompatible coatings for medical devices are disclosed. Specifically, polymer coatings designed to control the release of bioactive agents from medical devices in vivo are disclosed wherein the solubility parameters of polymers and drugs are closely matched to control elute rate profiles. The present application also discloses providing vascular stents with controlled release coatings and related methods for making these coatings.

Biocompatible controlled release coatings for medical devices and related methods

Biostable, multipurpose, microbicidal intravaginal devices in the form of rings, ringed-meshes, sponges, or diaphragms for use by women and condoms for use by male partners are provided, wherein each of the devices contains a drug effective in treating a particular vaginal infection, while further exhibiting at least one additional function selected from the group dealing with non-hormonal contraception, management of sexually transmitted diseases, viral infections, and retroviral infections as well as the treatment of cervical cancer.

Biostable, multipurpose, microbicidal intravaginal devices

Bioactive, hydroforming luminal liner compositions are formed of high molecular weight crystalline, absorbable copolyesters dissolved in a liquid derivative of a polyether glycol that undergoes transformation into a tissue-adhering, resilient interior cover or liner for the controlled release of its bioactive payload at clinically compromised conduits in humans as in the case of bacteria- and yeast-infected vaginal canals, esophagi, and arteries following angioplasty.

Absorbable crystalline copolyester-based bioactive hydroforming luminal liner compositions

Bioactive hydroforming luminal liner compositions are formed of an absorbable crystalline amphiphilic polyether-ester-urethane dissolved in a liquid derivative of a polyether glycol that undergoes transformation into a tissue-adhering, resilient interior cover or liner for the controlled release of its bioactive payload at clinically compromised conduits in humans as in the case of bacteria- and yeast-infected vaginal canals, esophagi, and arteries following angioplasty.

Absorbable crystalline polyether-ester-urethane-based bioactive luminal liner compositions

Biomedical and tissue engineering devices, such as surgical sutures and microporous scaffolds, respectively, which undergo swelling and increase in dimensions when placed in aqueous environments such as living tissues, are produced by the melt-spinning or electrostatic spinning into strong monofilament and multifilament yarns or microfibrous fabrics, respectively. Such devices are formed from especially high molecular weight crystalline polyether-esters having a minimum inherent viscosity of 0.8 dL/g and heat of fusion of at least 5 J/g, wherein the polyether-esters are made by grafting to a polyester component a polyether glycol component having a minimum molecular weight of about 11 kDa with at least one cyclic monomer.

Swellable fiber and microfiber forming polyether-esters and applications thereof

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Anderson, SC, United States of America

Shalaby Wahba Shalaby