National Institute of Immunology

Other

Shakti N Upadhyay

Suman Dhawan

Gursaran P Talwar

Madan G Sharma

D N K Sarma

Anita Kamra

Raman Prasad Yadav

Nalini Wali

Vikas Madan

Chanda Bose

Supriya Shukla

Amarjeet Singh

Sabari Ghosal

N K Saraswathi

Charu Kaushic

Ram A Vishwakarma

A method for blocking the attachment of leukocytes to endothelial cells/lining of the blood vessels using a plant derived protoberberine alkaloid, berberine or its pharmaceutically acceptable salts. This prevents tissue damage to the surrounding tissue. The method also can be used to prevent and/or treat clinical manifestations that involve endothelial cell-leukocyte attachment, for example septic shock, arthritis, psoriasis, multiple sclerosis, allergic asthma, metastatic melanoma and graft rejection.

Method for blocking endothelial cell-leukocyte attachment by inhibiting expression of adhesion molecules on the vascular endothelium for therapeutic applications

Berberine or pharmaceutically acceptable salts thereof either alone or in combination with cyclosporin can be used to treat or prevent graft vs. host disease. Berberine or pharmaceutically acceptable salts thereof can also be used to treat or prevent septic shock syndrome.

Methods for prevention and treatment of septic shock

A method for ex vivo expansion of the number of hematopoietic cells using a culture medium comprising an extract prepared from a plant of the Tinospora species and a method of ex vivo expansion of the number of hematopoietic cells by inducing IL-6 production by using a culture medium comprising an extract from a plant of the Tinospora species are described.

Method for ex-vivo expansion of hematopoietic cells

Method for suppressing allogenic immune response or prevention/treatment of graft vs. host disease or graft rejection

Process for isolation of 1-(3,4-methylenedioxy-phenyl)-1E-tetradecene from Piper longum. Processes for synthesis of 1-(3,4-methylenedioxy-phenyl)-1E-tetradecene; its stereoisomers and analogues are disclosed. The compounds isolated and synthesized according to this invention have immunomodulatory properties and can be used to treat tumors and infections.

Process for isolation and synthesis of 1-(3,4

A process for isolating berberine from plants is described. An oral formulation of berberine is described.

Application of protoberberine alkaloid, berberine, an immunosuppressive

An alternate approach to vasectomy for long term male contraception following a single intra-vas.application of a traditional plant (Azadirachta indica) product having immunomodulatory properties is described. The intra-vas administration of neem oil to male rats resulted in a block of spermatogenesis without affecting the testosterone production; the seminiferous tubules, although reduced in diameter, appeared normal and contained mostly early spermatogenic cells. No antisperm antibody could be detected in the serum. Unilateral administration of neem oil in the vas resulted in a significant reduction of testicular size and spermatogenic block only on the side of application; the draining lymph node cells of the treated side also showed enhanced proliferative response to in vitro mitogen challenge. These results indicate that intra-vas application of neem oil is effective in blocking fertility in male mammals after a single injection.

Neem oil as a male contraceptive

There is provided a means for reversible fertility control for prevention of pregnancy in female mammals for several months through the use of neem oil or its components, applied locally to the uterus. There is also provided a spermicidal composition containing neem oil or its components in combination with reetha extract as a vaginal cream.

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New Delhi, India

Shakti N Upadhyay