University of Michigan

Acceleron Pharma Inc.

Shailesh Agarwal

Benjamin Levi

Ravindra Kumar

In part, the present disclosure relates methods for treating heterotopic ossification or one or more complications of heterotopic ossification. In particular, the disclosure provided methods for treating heterotopic ossification by administering to a patient in need thereof one or more TGFβ antagonists, optionally in combination with one or more additional active agents or supportive therapies for treating heterotopic ossification. For example, in some embodiments, the disclosure provided methods for treating heterotopic ossifications by administering to a patient in need thereof an effective amount of a TβRII polypeptide.

Methods for treating heterotopic ossification

The invention provides a method of treating heterotopic ossification in a subject in need thereof. The method comprises administering a hypoxia inducible factor-1&#x3b1; (Hif-1&#x3b1;) inhibitor to the subject. In various embodiments, the Hif-1&#x3b1; inhibitor is PX-478, rapamycin, or digoxin.

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Ypsilanti, MI, United States of America

Shailesh Agarwal