Ranbaxy Laboratories, Inc.

Shailendra Kumar Singh

Yatendra Kumar

Neera Tiwari

Jag Mohan Khanna

Neera Tewari

Rakesh Kumar Arora

Subhash Dhar

Bhupendra Vashishta

Brij Kishore Mishra

Prashant Kumar Sharma

Saraswati Rani

The present invention relates to a process for the preparation of pure meropenem trihydrate.

Process for the preparation of pure meropenem trihydrate

The present invention relates to a process for the preparation of carbapenem compound of Formula (I), wherein Pis hydrogen or a carboxyl protecting group, Pis hydrogen or a hydroxyl protecting group, Ris Calkyl, and A is selected from a group consisting of a) Formula (II), b) Formula (III), c) Formula (IV), d) Formula (V), e) Formula (VI), f) Formula (VII), wherein Pis hydrogen or an amino protecting group, Rand Rmay be same or different and are hydrogen, Calkyl, optionally substituted aryl, or optionally substituted heteroaryl, and Xis O or S, or its stereoisomers, or salts thereof. 

Process for the preparation of carbapenem compounds

A method for preparing crystalline cefadroxil hemihydrate from cefadroxil dimethyl formamide solvate using a mixture of a lower alkanol and water.

Process for preparing crystalline cefadroxil hemihydrate from cefadroxil dimethylformamide solvate

A process for converting cephalosporin p-nitrobenzyl ester (Formula I) to the corresponding cephalosporin free acid (Formula II) comprising treating the cephalosporin p-nitrobenzyl ester with a metal selected from the group consisting of iron, magnesium, aluminum, and tin, and with hydrochloric acid in a mixture of water and a water-miscible organic solvent. Preferably, the metal is iron in the form of a fine powder, and the reaction is carried out at a temperature in the range of 30.degree.-50.degree. C.

Process for P-nitrobenzyl ester cleavage in cephalosporin

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Gurgaon, India

Shailendra Kumar Singh