Technion Research & Development Foundation Ltd

Leland Stanford Junior University

Health Corporation - Rambam

Other

Shai S Shen-Orr

Asya Rolls

Fahed Hakim

Tamar Ben Shannan

Maya Schiller

Elina Starosvetsky

Hilla Azulay-Debbie

Mark M Davis

Purvesh Khatri

Atul J Butte

Renaud Gaujoux

Ayelet Alpert

Francesco Vallania

Elina Starovetsky

Naama Maimon

David Furman

Brian A Kidd

Ashham Mansur

A method for modulating an immune response by activating or inhibiting dopaminergic neurons in the Ventral Tegmental Area (VTA) is provided. Modulation is achieved by modulating the activity, the abundance or both of: a natural killer cell, a CD8 T-cell, a CD4 T-cell, a B-cell, a dendritic cell, a macrophage, a granulocyte, or their combination.

Neuronal modulation

Provided are methods of predicting responsiveness of a subject having an inflammatory bowel disease (IBD) to a tumor necrosis factor (TNF)-alpha inhibitor, by analyzing a frequency of at least one subpopulation of immune cells in a tissue biopsy of the subject. Also provided are methods of selecting a treatment for a subject and kits for determining responsiveness of the subject to treatment with a TNF-alpha inhibitor.

Infiltrating immune cell proportions predict anti-TNF response in colon biopsies

Embodiments of the present invention provide diagnostic markers of immunosenescence and methods of identifying individuals with impaired immune function based on a combination of such markers obtained from various analyzes, primarily from blood, testing immune function including the analysis of immune cell subset frequencies, gene expression, cytokine and chemokine levels, and signaling responses to stimulation with cytokines ('cytokine response'). Particular combinations of markers can predict with high accuracy whether an individual will respond to active vaccination and become protected against recurring diseases.

Method of assaying an individual for immune impairment

Growing community of inventors

Karkur, Israel

Shai S Shen-Orr