Tagra Biotechnologies Ltd.

Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.

Shaher Duchi

Danny Goldstein

Olga Privalova

Lior Ben-Altabet

Yaniv Menachem

Hanan Haj

Elka Touitou

Audrey Ricard

Biana Godin

Multi-layer microcapsules comprising a core comprising one or more active agents and two or more shells comprised of a wall-forming polymeric material, an opaque substance and a fatty acid salt, which are rupturable upon rubbing or pressing on the skin, are disclosed. The microcapsules are characterized by improved lightness values (L*) and/or compatibility in aqueous solution-containing formulations. Cosmetic or cosmeceutic formulations comprising the microcapsules, which can be, for example, body skin care formulation or facial skin care formulations, are also provided.

Active agent-containing microcapsules

Microcapsules encapsulating a reflective agent are provided herein. The microcapsules are comprised of an inner core, which comprises the reflective agent and optionally an oily substance, and an outer shell formed of wall-forming polymeric materials. The microcapsules may further comprise an opaque substance and/or a fatty acyl salt in the outer shell. Processes of preparing the microcapsules are also provided.

Microcapsules encapsulating a reflective agent

The present invention concerns a method of administering at least one active pharmaceutical agent to a patient in need thereof, which method comprises the intranasal administration of a composition comprising a therapeutically effective amount of this agent, phospholipids, one or more C2-C4 alcohols and water, wherein the concentrations of the phospholipids and the one or more alcohols in the composition are in the ranges of 0.2 to 10% and 12 to 30% by weight, respectively, with the water content of said composition being not less than 30% by weight, the phospholipids forming vesicles in said composition. Further are disclosed pharmaceutical compositions and combinations suitable for intranasal delivery.

Compositions for nasal delivery

Growing community of inventors

Kfar Rama, Israel

Shaher Duchi