Applera Corporation

Life Technologies Corporation

Applied Biosystems, LLC

Pe Corporation (ny)

Pe Corporation

Shaheer Khan

Steven Menchen

Wolfgang Hinz

Barnett B Rosenblum

Meng Taing

Dmitriy Gremyachinskiy

Alan Blanchard

Prasanna Krishnan Thwar

Luisa Andruzzi

Alfred Lui

Paolo Vatta

Craig Stolarczyk

Peter Virgil Fisher

Tanya Sokolsky

Geun-sook Jeon

Scott C Benson

Kyle R Gee

Carl Williams Fuller

Weiguo Zhen

Daqing Sun

Hee Chol Kang

Alexander J Mastroianni

Joe Y L Lam

David Light

James Stray

Wenjun Zhou

Brian Lee Evans

Yolanda Tennico

Paul M Kenney

Diem Tran

Peter Slade

Barnett B Rosenbaum

Geunsook Jeon

Geir Fonnum

Jo Aaserud

Nini Kjus

Astrid Evenroed Molteberg

Grete Modahl

M Talha Gokmen

A method of conjugating a substrate includes exchanging a counter ion associated with a biomolecule with a lipophilic counter ion to form a biomolecule complex, dispersing the biomolecule complex in a nonaqueous solvent, and coupling the biomolecule complex to a substrate in the presence of the nonaqueous solvent.

Conjugated polymeric particle and method of making same

The present disclosure is directed dye compounds containing a hydrazinyl substituent and optionally, one or more negatively charged groups, such as sulfonate, phosphate, phosphonate, and/or carboxylate groups and dye compounds containing an aminooxy substitutent. The compounds are useful in the detection of analytes containing aldehyde and ketone groups, including, for example, glycans.

Hydrazinyl and aminooxy compounds and their methods of use

Methods, systems, compositions and kits are described for detecting cleaved glycans from a glycoconjugate. After labeling the glycan with a nucleic acid charged oligomer described herein, the labeled glycans can be separated under the influence of an electric field or based on their detectable tag and identified.

Charged reactive oligomers

Disclosed are methods and kits applicable to sequencing methods, such as Sanger dideoxy sequencing methods. The methods and kits disclosed utilize a cationically charged nucleic acid terminator in combination with a discriminatory polymerase.

Nucleic acid terminators incorporating a cationic moiety and methods for their use

Disclosed, among other things, are compounds having the structure wherein X comprises a bond or a linker, LABEL comprises at least one detectable label, Wtaken alone is &#x2014;H or &#x2014;OH, Wis &#x2014;OH or a non-extendable moiety, Wwhen taken alone is &#x2014;H or when taken together with Wis &#x2014;CH&#x2014;O&#x2014;, and Wis OH, monophosphate, diphosphate, or triphosphate. Also disclosed are labeled polynucleotide compounds and methods of use thereof.

Propargyl substituted nucleoside compounds and methods

The invention provides novel dye-labeled ribonucleotide analogs and methods for synthesizing those analogs. The compounds of the invention are especially useful for DNA sequencing by the polymerase chain reaction.

Dye-labeled ribonucleotide triphosphates

Provided are nucleotide-dye conjugates and related compounds in which a dye is linked to a nucleobase directly or indirectly by an anionic linker. The anionic character of the linker is provided by one or more anionic moieties which are present in the linker, such as phosphate, phosphonate, sulfonate, and carboxylate groups. When the dye is a provided as a donor/acceptor dye pair, the anionic linker can be located between the donor and the acceptor, or between the nucleobase and either the donor or acceptor, or both. In one embodiment, conjugates of the invention provide enhanced electrophoretic mobility characteristics to sequencing fragments, e.g., for dideoxy sequencing using labeled terminators.

Fluorescent nucleobase conjugates having anionic linkers

Compounds, methods and kits for making and analyzing primer extension products incorporating one or more universal bases are described, including methods and kits for nucleic acid sequencing and microsatellite analysis.

Universal bases for nucleic acid analyses, methods for using universal bases, and kits comprising universal bases

Growing community of inventors

Foster City, CA, United States of America

Shaheer Khan