Abbott Cardiovascular Systems, Inc.

Shadid Askar

Mikael Trollsas

John Joseph Stankus

Syed F Hossainy

James Su

Joshua Smith

Formulations and methods are disclosed which provide controlled, sustained release of a biologic therapeutic to a space within the body. More specifically, formulations comprising a plurality of hydrophilic polymer strands, and methods of forming and administering such formulations, are disclosed. In some embodiments, the formulations exhibit a burst release, an initial release, a triphasic release, and release over thirty to ninety days of the biologic therapeutic. In some embodiments, the formulations exhibit reversible precipitation of the biologic therapeutic into precipitates having a diameter of about 50 nm to about 10 &#x3bc;m.

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Round Rock, TX, United States of America

Shadid Askar