Alveo Technologies, Inc.

Entegris, Inc.

Entegris-jetalon Solutions, Inc.

Shad Pierson

Ronald Phillip Chiarello

Kyle William Montgomery

Daniel J Wade

Yuh-Min Chiang

Mark Alan Arbore

Christopher Wacinski

Yevgeny Anoikin

Brenna Hearn Lord

Jess M Sustarich

Timothy D Meehan

The present application is generally directed to systems, methods, and devices for diagnostics for sensing and/or identifying pathogens, genomic materials, proteins, and/or other small molecules or biomarkers. In some implementations, a small footprint low cost device provides rapid and robust sensing and identification. Such a device may utilize microfluidics, biochemistry, and electronics to detect one or more targets at once in the field and closer to or at the point of care. In some implementations, the systems and methods herein implement a reader device, an assay cartridge, and a mobile or external device configured to receive abiological sample, test the biological sample, and provide test results to a patient or user associated with the patient. The test results may be packaged with additional information, including symptoms suffered by the patient, a diagnosis, and follow-up instructions. In some embodiments, the test results may also be provided with or aggregated with other test results to generate aggregate information.

Handheld impedance-based diagnostic test system for detecting analytes

The present application is generally directed to systems, methods, and devices for diagnostics for sensing and/or identifying pathogens, genomic materials, proteins, and/or other small molecules or biomarkers. In some implementations, a small footprint low cost device provides rapid and robust sensing and identification. Such a device may utilize microfluidics, biochemistry, and electronics to detect one or more targets at once in the field and closer to or at the point of care.

Methods and compositions for detecting analytes

Reader device for a diagnostic system

Diagnostic reader device

An optical sensor apparatus includes an optically transmissive structure (e.g., a prism) having two planar faces and a third planar face that connects the two planar faces, two or more light sources located outside the structure, and a photodetector array located outside the prism. The structure, light sources, and photodetector array are configured such that light from the light sources that is totally internally reflected at an optical interface between the prism and a sample outside the structure proximate one of the two planar faces is incident on a portion of the photodetector array that depends on a refractive index of the sample. The light sources are positioned with respect to the structure and photodetector array such that the totally internally reflected light from each light source corresponds to a different range of refractive index of the sample and maps to a corresponding portion of the photodetector array.

Optical sensor apparatus to detect light based on the refractive index of a sample

An optical sensor apparatus includes an optically transmissive structure having planar first, second, and third faces, two or more light sources located outside the structure adjacent the first face, and a photodetector array located outside the prism adjacent the first face. The structure, light sources, and photodetector array are configured such that light from the light sources that is totally internally reflected at an optical interface between the prism and a sample outside the structure proximate the second face is reflected at the third face and incident on a portion of the photodetector array that depends on a refractive index of the sample. The light sources are positioned with respect to the structure and photodetector array such that the totally internally reflected light from each light source corresponds to a different range of refractive index of the sample and maps to a corresponding portion of the photodetector array.

Growing community of inventors

Walnut Creek, CA, United States of America

Shad Pierson