Becton Dickinson France

Becton Dickinson and Company Limited

Sébastien Jouffray

Cédric Rivier

Jean-Bernard Hamel

Cédric Foucher

Benoit Fremon

Nicolas Euvrard

Tzvetelina Chevolleau

Alfred Leibbrand

Yves Enfoux

Paolo Mangiagalli

Nicolas Bralet

Nicolas Deleuil

Fabien Bonhoure

Sébastien Janvier

The invention relates to a method for reducing an amount of sub visible particles in a pharmaceutical composition contained in a medical injection device comprising a container () including a barrel () lubricated with a lubricant coating () in contact with the pharmaceutical composition, and a stopper () in sliding engagement within the barrel (), the container comprising a region () extending distally from the distal end () of the barrel which is not accessible to the stopper. During formation of said lubricant coating () on the inner wall of the barrel, the method comprises limiting lubricant from being deposited into said region () extending distally from the distal end () of the barrel.

Method for reducing an amount of subvisible particles in a pharmaceutical composition

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Saint Martin d'Uriage, France

Sébastien Jouffray