American Cyanamid Company

Seymour Bernstein

Ransom B Conrow

Joseph P Joseph

John F Poletto

Vijay G Nair

Robert Herman Lenhard

Robert E Schaub

Gerald J Siuta

John P Dusza

Janis Upeslacis

Milton David Heller

Thomas G Miner

Norman Bauman

Arthur J Lewis

Francis M Callahan

Miner Thomas G

This invention relates to novel 3-amino-1-heteroaryl-2-pyrazolines and their C.sub.4 and C.sub.5 analogs, useful for meliorating the inflammation and/or the progressive joint deterioration characteristic of arthritic disease, preventing the onset of asthmatic symptoms and allergic diseases, or as analgesic, antibacterial or antifungal agents.

Heterocyclic substituted-amino-pyrazolines

Polyanionic benzene ureas and salts thereof useful as complement inhibitors.

Polyanionic benzene ureas

Multisulfonated naphthalene ureas, useful as complement inhibitors.

Multisulfonated naphthalene ureas useful as complement inhibitors

This invention concerns novel compounds useful in compositions and methods for preventing the attachment of dental plaque to the surfaces of the teeth of mammals and as inhibitors of connective tissue destruction. The compounds of this invention comprise certain [oxalylbis(iminophenylenecarbonylimino)]bis[hydroxynaphthalenesulfonic acids] and salts thereof which may be combined with pharmaceutically acceptable carriers or diluents to be administered in the form of conventional pharmaceutical compositions.

Oxalylamides useful as dental antiplaque agents and inhibitors of

This invention concerns novel compounds useful in compositions and methods for preventing the attachment of dental plaque to the surfaces of the teeth of mammals and as inhibitors of connective tissue destruction. The compounds of this invention comprise certain [ureylenebis-(phenylenesulfonylimino)]bis[hydroxynaphthalenesulfonic acids] and salts thereof which may be combined with pharmaceutically acceptable carriers or diluents to be administered in the form of conventional pharmaceutical compositions.

Dental antiplaque agents and inhibitors of connective tissue destruction

A method of inhibiting the complement system using multisulfonated naphthalene ureas.

Method of inhibiting the complement system by administering

Cation salts of substituted phenyl-1-thio(poly-O-sulfo)-.alpha.(or .beta.)-D-glucopyranoside, useful as modulators of the complement system, the intermediates thereof and the process of making such intermediates and end products.

Substituted phenyl-1-thio(poly-O-sulfo)-.alpha.(or

Poly-cation salts of 4-O-polyhexaose-thio-arylene sulfate derivatives, useful as modulators of the complement system, the intermediates thereof and the process of making such intermediates and products.

Poly-cation salt of 4-O-polyhexaose-thio-arylene sulfates

Poly-cation salts of 4-O-polyhexaose-thio-alkylene sulfate derivatives, useful as modulators of the complement system, the intermediates thereof and the process of making such intermediates and products.

Poly-cation salts of 4-O-poly-hexaose-thio-alkylene sulfate derivatives

Bis-[.beta.-D-glucopyranosyl-1-thio (or sulfinyl or sulfonyl)]-arylene sulfate derivatives, the cation salts thereof, useful as modulators of the complement system, the intermediates thereof and the process for the preparation of such intermediates and end products.

Method of modulating the complement system by administering

A method of meliorating the inflammation and/or the progressive joint deterioration characteristic of arthritic disease, preventing the onset of asthmatic symptoms and allergic diseases, treating pain or treating bacterial and fungal infections in mammals using 3-amino-1-halogenated phenyl-2-pyrazolines and their C4 and C5 analogs.

Therapeutically active 3-amino-1-halogenated phenyl-2-pyrazolines and

3-substituted amino-1-phenyl-2-pyrazolines and 3-substituted amino-1-substituted phenyl-2-pyrazolines and their C.sub.4 and C.sub.5 analogs, useful for meliorating the inflammation and/or the progressive joint deterioration characteristic of arthritic disease, preventing the onset of asthmatic symptoms and allergic diseases, or as analgesic, antibacterial or antifungal agents.

Therapeutically active 3-substituted amino-1-phenyl and substituted

Poly-cation salts of bis(or tris)[4-O-monohexose-oxy]-arylene sulfate derivatives useful as modulators of the complement system, the intermediates thereof and the process of making such intermediates and products.

Poly-cation salts of bis(or tris)[4-O-monohexose-oxy]-arylene sulfate

Poly-cation salts of bis (or tris) 4-O-polyhexose-thio-arylene sulfate derivatives, useful as modulators of the complement system, the intermediates thereof and the process of making such intermediates and end products.

Poly-cation salts of bis (or tris) 4-O-polyhexose-thio-arylene sulfate

This disclosure describes certain 3-amino-1-phenyl-2-pyrazolines and 3-amino-1-substituted phenyl-2-pyrazolines and their C4 and C5 analogs useful for meliorating the inflammation and/or the progressive joint deterioration characteristic of arthritic disease, preventing the onset of asthmatic symptoms and allergic diseases, or as analgesic, antibacterial or antifungal agents.

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New City, NY, United States of America

Seymour Bernstein