The United States of America, As Represented by the Secretary, Department of Health and Human Services

Ufpeptides S.r.l.

The United States of America As Represented by the Department of Health

Severo Salvadori

Lawrence H Lazarus

Remo Guerrini

Girolamo Calo′

Domenico Regoli

Girolamo Calo'

Piero Andrea Temussi

The invention relates to a supramolecular aggregate of formula (VI) wherein A is an active substance, and X, X, Xand X, independently to each other, are a moiety of Formula (I) containing a maleimido functionalization and at least one among X, X, Xand Xis present in Formula (VI). In a preferred embodiment the maleimido-functionalized core is PWT2. The supra-molecular aggregate can be used in the field of drugs, vaccines, as ligands for GPCR, i.e. agonists as well as antagonist, as antibiotics and as diagnostics eventually in complex with radionuclides.

Supramolecular aggregates comprising maleimido cores

Peptide analogs of nociceptin/orphanin FQ, compositions thereof, and their use in treatment of disorders and dysfunctions related to activation or blocking of NOP receptors are described.

Highly potent full and partial agonists and antagonists of the nociceptin/orphanin FQ receptor

A compound of formula:wherein X is a spacer comprising one or more amino acid residues and Y comprises an aromatic group and related compositions and methods of use.

Dmt-Tic di-and tri-peptidic derivatives and related compositions and methods of use

Dmt-Tic di- and tri-peptide derivatives and related compositions and methods of use

Novel opioidmimetic dipeptides, tripeptides and cyclic peptides exhibit enhanced affinity and selectivity for .delta. opioid receptors. The peptides are represented by the formulas L/D-Dmt-L-/D-Tic-R', L/D-Dmt-L-/D-Tic-R-R' and cyclic (L/D-Dmt-L/D-Tic) wherein Dmt is 2',6',-dimethyl-L/D-tyrosine Tic is L-/D-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid, R is a natural or unusual aliphatic amino residue and R' is a functional group at the carboxyl terminus of the peptide. Pharmacological and therapeutic and compositions are also provided.

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Ferrara, Italy

Severo Salvadori