Regeneran Pharmaceuticals, Inc.

Seungyong Sean Choi

Thomas Nittoli

Mrinmoy Saha

The disclosure relates to rifamycin analog compounds, intermediates and precursors thereof, and pharmaceutical compositions capable of inhibiting bacterial growth (e.g.,growth) and treating bacterial infections (e.g.,infections). The disclosure further relates to antibody-drug conjugates of rifamycin analog compounds and antibodies, for example, antibodies specific for infectious disease-related targets such as membrane glycoprotein receptor (MSR1), wall teichoic acids (WTA) or Protein A, and methods of use thereof to inhibit bacterial growth and treat bacterial infections.

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Bristol, PA, United States of America

Seungyong Sean Choi