University of Illinois

Massachusetts Institute of Technology

Wisconsin Alumni Research Foundation

The University of Chicago

University of Cincinnati

Seungpyo Hong

Robert Samuel Langer

Daniel Griffith Anderson

Jeffrey Michael Karp

Rohit Nandkumar Karnik

Suman Bose

Ying Mei

Xi Jason Jiang

Jianjun Chen

Jin Woo Bae

Zejuan Li

Ja Hye Myung

Ying Liu

David T Eddington

Sin-Jung Park

Yang Yang

Michael J Poellmann

Cari Launiere

Woo-jin Jeong

Described herein is cancer biomarker, e.g., a vesicle, capture surface that includes a substrate, a first plurality of nanoparticles attached to the substrate; a plurality of bifunctional tethers, wherein a first functionality of the bifunctional tethers is attached to at least a portion of the first plurality of nanoparticles; a second plurality of nanoparticles attached to a second functionality of at least a portion of the plurality of bifunctional tethers; a capture agent attached to at least a portion of the second plurality of nanoparticles; and a plurality of polymer brush molecules attached to the surface, wherein the polymer brush molecules have a lower molecular weight than the bifunctional tethers, and wherein the polymer brush molecules reduce nonspecific binding to the surface. Also described are method of capturing cancer biomarkers such as vesicles from a liquid biopsy sample.

Nanoengineered surfaces for cancer biomarker capture

A nanoparticle delivery system designed for sustained delivery of microRNA-150 (miR-150) to FLT3-overexpressing acute myeloid leukemia (AML) cells, the delivery system comprising poly(amidoamine) (PAMAM) dendrimers complexed with miR-150, wherein at least one dendrimer is surface-functionalized with a ligand specific for FLT3 receptor, and methods for treating AML characterized by FLT3-overexpression are provided.

Methods for treating subjects suffering from acute myeloid leukemia with FLT3 ligand-targeted miR-150 nanoparticles

Described herein is a nanoparticle system including a multivalent nanoparticle core having a plurality of &#x3b2;-hairpin peptides conjugated thereto. Also included are pharmaceutical compositions and methods of making the nanoparticle system. Further included are immunotherapy methods including administering the nanoparticle system to a subject in need thereof, such as a human cancer patient.

Peptide-nanoparticle conjugates

Described herein are hybrid nanoparticles that are exosomes loaded with one or more nanoparticle dendrimers. Also included are pharmaceutical compositions including the hybrid nanoparticles and methods of making the hybrid nanoparticles. Also described is a method of treating a human subject by administering to the human subject the above-described hybrid nanoparticles.

Dendrimer-exosome hybrid nanoparticles as a delivery platform

A method of capturing a Circulating Tumor Cell (CTC) and Circulating Cancer Cells (CSC) from a sample includes introducing a sample into a flow based multichannel device having a cell capture surface and a flow modification surface under conditions that allow a CTC to bind to a cell rolling-inducing agent and a capturing agent disposed on the cell capture surface. The invention also provides for flow based multichannel devices to capture CTCs and CSCs from a sample.

Biomimetic microfluid device for capturing circulating tumor cells

The invention generally relates to the field of drug delivery. In particular, the invention relates to amphiphilic dendron-coils, micelles thereof and their use for the transdermal delivery of drugs.

Dermal drug delivery using amphiphilic dendron-coil micelles

The present invention provides systems for cell separation based on cell rolling on surfaces along edges of regions coated with cell adhesion molecules. A variety of designs of coated regions and edges are disclosed.

Cell rolling separation

A method of capturing a Circulating Tumor Cell (CTC) from a sample includes introducing a sample into a microfluidic device having a cell capture surface and a flow modification surface under conditions that allow a CTC to bind to a cell rolling-inducing agent and a capturing agent disposed on the cell capture surface. The flow modification surface induces a rotational flow within the sample as it flows through the microfluidic device.

Method and devices for capturing circulating tumor

The invention generally relates to the fields of drug delivery and cell capture. In particular, the invention relates to amphiphilic dendron-coils, micelles thereof and their use for drug delivery vehicles and/or cell capture.

Amphiphilic dendron-coils, micelles thereof and uses

The present invention features nanohybrid drug delivery composition which combines both passive and active targeting for the prevention and treatment of disease. The composition is shell-encapsulated multivalent polymeric scaffold with a therapeutic agent and targeting agent attached thereto.

Growing community of inventors

Naperville, IL, United States of America

Seungpyo Hong